Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute
Abstract Background The aim of this study was to evaluate the combined use of the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) as an assessment tool for urinary symptom flare after iodine-125 (125I) implant brachytherapy. The association between urinary sy...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Urology |
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| Online Access: | http://link.springer.com/article/10.1186/s12894-017-0251-1 |
| _version_ | 1811215378971361280 |
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| author | Makito Miyake Nobumichi Tanaka Isao Asakawa Shunta Hori Yosuke Morizawa Yoshihiro Tatsumi Yasushi Nakai Takeshi Inoue Satoshi Anai Kazumasa Torimoto Katsuya Aoki Masatoshi Hasegawa Tomomi Fujii Noboru Konishi Kiyohide Fujimoto |
| author_facet | Makito Miyake Nobumichi Tanaka Isao Asakawa Shunta Hori Yosuke Morizawa Yoshihiro Tatsumi Yasushi Nakai Takeshi Inoue Satoshi Anai Kazumasa Torimoto Katsuya Aoki Masatoshi Hasegawa Tomomi Fujii Noboru Konishi Kiyohide Fujimoto |
| author_sort | Makito Miyake |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to evaluate the combined use of the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) as an assessment tool for urinary symptom flare after iodine-125 (125I) implant brachytherapy. The association between urinary symptom flare and prostate-specific antigen (PSA) bounce was investigated. Methods Changes in the IPSS and OABSS were prospectively recorded in 355 patients who underwent seed implantation. The percentage distribution of patients according to the difference between the flare peak and post-implant nadir was plotted to define significant increases in the scores. The clinicopathologic characteristics, treatment parameters, and post-implant dosimetric parameters were compared between the non-flare and flare groups. PSA bounce was defined as an elevation of ≥0.1 ng/mL or ≥0.4 ng/mL compared to the previous lowest value, followed by a decrease to a level at or below the pre-bounce value. Results A clinically significant increase required an IPSS increase of at least 12 points and an OABSS increase of at least 6 points based on a time-course analysis of total scores and the QOL index. Assessment only by IPSS failed to detect 40 patients (11%) who had urinary symptom flare according to the OABSS. Univariate and multivariate analyses revealed that patients treated with higher biologically effective doses and those without diabetes mellitus had higher risks of urinary flare. There was no statistical correlation between the incidence and time of urinary symptom flare onset and that of a PSA bounce. Conclusions To our knowledge, this is the first report to prove the clinical potential of the OABSS as an assessment tool for urinary symptom flare after seed implantation. Our findings showed that persistent lower urinary tract symptoms after seed implantation were attributed to storage rather than to voiding issues. We believe that assessment with the OABSS combined with the IPSS would aid in decision-making in terms of timing, selection of a treatment intervention, and assessment of the outcome. |
| first_indexed | 2024-04-12T06:21:40Z |
| format | Article |
| id | doaj.art-ae896b85ecd74baeb257a8640698023b |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-04-12T06:21:40Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-ae896b85ecd74baeb257a8640698023b2022-12-22T03:44:17ZengBMCBMC Urology1471-24902017-08-0117111110.1186/s12894-017-0251-1Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single instituteMakito Miyake0Nobumichi Tanaka1Isao Asakawa2Shunta Hori3Yosuke Morizawa4Yoshihiro Tatsumi5Yasushi Nakai6Takeshi Inoue7Satoshi Anai8Kazumasa Torimoto9Katsuya Aoki10Masatoshi Hasegawa11Tomomi Fujii12Noboru Konishi13Kiyohide Fujimoto14Department of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Radiation Oncology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityDepartment of Radiation Oncology, Nara Medical UniversityDepartment of Pathology, Nara Medical UniversityDepartment of Pathology, Nara Medical UniversityDepartment of Urology, Nara Medical UniversityAbstract Background The aim of this study was to evaluate the combined use of the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) as an assessment tool for urinary symptom flare after iodine-125 (125I) implant brachytherapy. The association between urinary symptom flare and prostate-specific antigen (PSA) bounce was investigated. Methods Changes in the IPSS and OABSS were prospectively recorded in 355 patients who underwent seed implantation. The percentage distribution of patients according to the difference between the flare peak and post-implant nadir was plotted to define significant increases in the scores. The clinicopathologic characteristics, treatment parameters, and post-implant dosimetric parameters were compared between the non-flare and flare groups. PSA bounce was defined as an elevation of ≥0.1 ng/mL or ≥0.4 ng/mL compared to the previous lowest value, followed by a decrease to a level at or below the pre-bounce value. Results A clinically significant increase required an IPSS increase of at least 12 points and an OABSS increase of at least 6 points based on a time-course analysis of total scores and the QOL index. Assessment only by IPSS failed to detect 40 patients (11%) who had urinary symptom flare according to the OABSS. Univariate and multivariate analyses revealed that patients treated with higher biologically effective doses and those without diabetes mellitus had higher risks of urinary flare. There was no statistical correlation between the incidence and time of urinary symptom flare onset and that of a PSA bounce. Conclusions To our knowledge, this is the first report to prove the clinical potential of the OABSS as an assessment tool for urinary symptom flare after seed implantation. Our findings showed that persistent lower urinary tract symptoms after seed implantation were attributed to storage rather than to voiding issues. We believe that assessment with the OABSS combined with the IPSS would aid in decision-making in terms of timing, selection of a treatment intervention, and assessment of the outcome.http://link.springer.com/article/10.1186/s12894-017-0251-1Prostate cancerBrachytherapyInternational Prostate Symptom ScoreOveractive bladder symptom scoreBiologically effective dosePSA bounce |
| spellingShingle | Makito Miyake Nobumichi Tanaka Isao Asakawa Shunta Hori Yosuke Morizawa Yoshihiro Tatsumi Yasushi Nakai Takeshi Inoue Satoshi Anai Kazumasa Torimoto Katsuya Aoki Masatoshi Hasegawa Tomomi Fujii Noboru Konishi Kiyohide Fujimoto Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute BMC Urology Prostate cancer Brachytherapy International Prostate Symptom Score Overactive bladder symptom score Biologically effective dose PSA bounce |
| title | Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute |
| title_full | Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute |
| title_fullStr | Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute |
| title_full_unstemmed | Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute |
| title_short | Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute |
| title_sort | assessment of lower urinary symptom flare with overactive bladder symptom score and international prostate symptom score in patients treated with iodine 125 implant brachytherapy long term follow up experience at a single institute |
| topic | Prostate cancer Brachytherapy International Prostate Symptom Score Overactive bladder symptom score Biologically effective dose PSA bounce |
| url | http://link.springer.com/article/10.1186/s12894-017-0251-1 |
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