Natural Bred ε<sup>2</sup>-Phages Have an Improved Host Range and Virulence against Uropathogenic <i>Escherichia coli</i> over Their Ancestor Phages

Natural Bred ε<sup>2</sup>-Phages Have an Improved Host Range and Virulence against Uropathogenic <i>Escherichia coli</i> over Their Ancestor Phages

Alternative treatments for <i>Escherichia coli</i> infections are urgently needed, and phage therapy is a promising option where antibiotics fail, especially for urinary tract infections (UTI). We used wastewater-isolated phages to test their lytic activity against a panel of 47 <i>...

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Bibliographic Details
Main Authors: Maria Loose, David Sáez Moreno, Michele Mutti, Eva Hitzenhammer, Zehra Visram, David Dippel, Susanne Schertler, Lenka Podpera Tišáková, Johannes Wittmann, Lorenzo Corsini, Florian Wagenlehner
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Antibiotics
Subjects:
phage therapy
phage breeding
<i>E. coli</i>
urinary tract infections
phage training
homologous recombination
Online Access:https://www.mdpi.com/2079-6382/10/11/1337

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