Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
The authors report that endothelial protocadherin FAT1 inhibits endothelial proliferation and angiogenesis by promoting degradation of the transcriptional cofactors YAP and TAZ by direct interaction with the E3 ubiquitin ligase Mind Bomb-2 (MIB2).
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37671-x |
| _version_ | 1797849986057109504 |
|---|---|
| author | Rui Li Jingchen Shao Young-June Jin Haruya Kawase Yu Ting Ong Kerstin Troidl Qi Quan Lei Wang Remy Bonnavion Astrid Wietelmann Francoise Helmbacher Michael Potente Johannes Graumann Nina Wettschureck Stefan Offermanns |
| author_facet | Rui Li Jingchen Shao Young-June Jin Haruya Kawase Yu Ting Ong Kerstin Troidl Qi Quan Lei Wang Remy Bonnavion Astrid Wietelmann Francoise Helmbacher Michael Potente Johannes Graumann Nina Wettschureck Stefan Offermanns |
| author_sort | Rui Li |
| collection | DOAJ |
| description | The authors report that endothelial protocadherin FAT1 inhibits endothelial proliferation and angiogenesis by promoting degradation of the transcriptional cofactors YAP and TAZ by direct interaction with the E3 ubiquitin ligase Mind Bomb-2 (MIB2). |
| first_indexed | 2024-04-09T18:53:02Z |
| format | Article |
| id | doaj.art-ae8cf225971e49d0b6bc0f0653d4b7c5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T18:53:02Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ae8cf225971e49d0b6bc0f0653d4b7c52023-04-09T11:20:27ZengNature PortfolioNature Communications2041-17232023-04-0114111710.1038/s41467-023-37671-xEndothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2Rui Li0Jingchen Shao1Young-June Jin2Haruya Kawase3Yu Ting Ong4Kerstin Troidl5Qi Quan6Lei Wang7Remy Bonnavion8Astrid Wietelmann9Francoise Helmbacher10Michael Potente11Johannes Graumann12Nina Wettschureck13Stefan Offermanns14Max Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Angiogenesis & Metabolism LaboratoryMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Small Animal Imaging Service GroupAix Marseille Université, CNRS, IBDM UMR 7288, Parc Scientifique de Luminy, Case 907Max Planck Institute for Heart and Lung Research, Angiogenesis & Metabolism LaboratoryMax Planck Institute for Heart and Lung Research, Biomolecular Mass Spectrometry Service GroupMax Planck Institute for Heart and Lung Research, Department of PharmacologyMax Planck Institute for Heart and Lung Research, Department of PharmacologyThe authors report that endothelial protocadherin FAT1 inhibits endothelial proliferation and angiogenesis by promoting degradation of the transcriptional cofactors YAP and TAZ by direct interaction with the E3 ubiquitin ligase Mind Bomb-2 (MIB2).https://doi.org/10.1038/s41467-023-37671-x |
| spellingShingle | Rui Li Jingchen Shao Young-June Jin Haruya Kawase Yu Ting Ong Kerstin Troidl Qi Quan Lei Wang Remy Bonnavion Astrid Wietelmann Francoise Helmbacher Michael Potente Johannes Graumann Nina Wettschureck Stefan Offermanns Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2 Nature Communications |
| title | Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2 |
| title_full | Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2 |
| title_fullStr | Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2 |
| title_full_unstemmed | Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2 |
| title_short | Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2 |
| title_sort | endothelial fat1 inhibits angiogenesis by controlling yap taz protein degradation via e3 ligase mib2 |
| url | https://doi.org/10.1038/s41467-023-37671-x |
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