Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equation
In the present study, the optimization of hyperthermia treatment via Magnetic nanoparticles (MNPs) direct injection using heuristic algorithms is conducted. The particles mass transfer in addition to the dual phase lag (DPL) bioheat equation are solved using implicit finite different scheme to captu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
|
| Series: | Ain Shams Engineering Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090447920301386 |
| _version_ | 1818576984227184640 |
|---|---|
| author | Reza Roohi Salman Baromand Homayoun Emdad Mohammad Reza Mahmoudi |
| author_facet | Reza Roohi Salman Baromand Homayoun Emdad Mohammad Reza Mahmoudi |
| author_sort | Reza Roohi |
| collection | DOAJ |
| description | In the present study, the optimization of hyperthermia treatment via Magnetic nanoparticles (MNPs) direct injection using heuristic algorithms is conducted. The particles mass transfer in addition to the dual phase lag (DPL) bioheat equation are solved using implicit finite different scheme to capture the temperature variations due to sever heat generation at early stages. To examine the capability and accuracy of the proposed algorithm three different tumor configurations are considered and the multi-site injection properties including number of infusions, location and time duration of injection(s) and MNP dosage is determined. According to the results, for primitive tumor shapes a tradeoff between accuracy and MNP consumption should be accounted, while 4-point injection provides the desired temperature pattern for complex tumor distributions. |
| first_indexed | 2024-12-16T06:22:42Z |
| format | Article |
| id | doaj.art-ae8cf7608aa445eab8c56054003d25b9 |
| institution | Directory Open Access Journal |
| issn | 2090-4479 |
| language | English |
| last_indexed | 2024-12-16T06:22:42Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ain Shams Engineering Journal |
| spelling | doaj.art-ae8cf7608aa445eab8c56054003d25b92022-12-21T22:41:05ZengElsevierAin Shams Engineering Journal2090-44792021-03-01121901915Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equationReza Roohi0Salman Baromand1Homayoun Emdad2Mohammad Reza Mahmoudi3Department of Mechanical Engineering, College of Engineering, Fasa University, 74617-81189 Fasa, IranDepartment of Electrical Engineering, College of Engineering, Fasa University, 74617-81189 Fasa, IranSchool of Mechanical Enginerring, Shiraz University, Shiraz, IranInstitute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam; Department of Statistics, Faculty of Science, Fasa University, 74617-81189 Fasa, Iran; Corresponding author at: Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.In the present study, the optimization of hyperthermia treatment via Magnetic nanoparticles (MNPs) direct injection using heuristic algorithms is conducted. The particles mass transfer in addition to the dual phase lag (DPL) bioheat equation are solved using implicit finite different scheme to capture the temperature variations due to sever heat generation at early stages. To examine the capability and accuracy of the proposed algorithm three different tumor configurations are considered and the multi-site injection properties including number of infusions, location and time duration of injection(s) and MNP dosage is determined. According to the results, for primitive tumor shapes a tradeoff between accuracy and MNP consumption should be accounted, while 4-point injection provides the desired temperature pattern for complex tumor distributions.http://www.sciencedirect.com/science/article/pii/S2090447920301386MNP hyperthermiaSimulation annealingMulti-site injectionArbitrary tumor shapeDual phase lag |
| spellingShingle | Reza Roohi Salman Baromand Homayoun Emdad Mohammad Reza Mahmoudi Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equation Ain Shams Engineering Journal MNP hyperthermia Simulation annealing Multi-site injection Arbitrary tumor shape Dual phase lag |
| title | Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equation |
| title_full | Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equation |
| title_fullStr | Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equation |
| title_full_unstemmed | Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equation |
| title_short | Optimization of focused multi-site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on MNP hyperthermia: Implementation of dual phase lag bioheat equation |
| title_sort | optimization of focused multi site injection therapy to provide the desired temperature pattern for arbitrary tumor configuration based on mnp hyperthermia implementation of dual phase lag bioheat equation |
| topic | MNP hyperthermia Simulation annealing Multi-site injection Arbitrary tumor shape Dual phase lag |
| url | http://www.sciencedirect.com/science/article/pii/S2090447920301386 |
| work_keys_str_mv | AT rezaroohi optimizationoffocusedmultisiteinjectiontherapytoprovidethedesiredtemperaturepatternforarbitrarytumorconfigurationbasedonmnphyperthermiaimplementationofdualphaselagbioheatequation AT salmanbaromand optimizationoffocusedmultisiteinjectiontherapytoprovidethedesiredtemperaturepatternforarbitrarytumorconfigurationbasedonmnphyperthermiaimplementationofdualphaselagbioheatequation AT homayounemdad optimizationoffocusedmultisiteinjectiontherapytoprovidethedesiredtemperaturepatternforarbitrarytumorconfigurationbasedonmnphyperthermiaimplementationofdualphaselagbioheatequation AT mohammadrezamahmoudi optimizationoffocusedmultisiteinjectiontherapytoprovidethedesiredtemperaturepatternforarbitrarytumorconfigurationbasedonmnphyperthermiaimplementationofdualphaselagbioheatequation |