The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits
Background: Pyrethroid insecticides are commonly used in residential settings, and their use has increased rapidly. Although research has been scarce, they have been reported to be associated with impaired neurodevelopment. Moreover, susceptible exposure windows and the long-term effects of pyrethro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022000502 |
| _version_ | 1818988184464261120 |
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| author | Kyung-Shin Lee Youn-Hee Lim Young Ah Lee Choong Ho Shin Bung-Nyun Kim Yun-Chul Hong Johanna Inhyang Kim |
| author_facet | Kyung-Shin Lee Youn-Hee Lim Young Ah Lee Choong Ho Shin Bung-Nyun Kim Yun-Chul Hong Johanna Inhyang Kim |
| author_sort | Kyung-Shin Lee |
| collection | DOAJ |
| description | Background: Pyrethroid insecticides are commonly used in residential settings, and their use has increased rapidly. Although research has been scarce, they have been reported to be associated with impaired neurodevelopment. Moreover, susceptible exposure windows and the long-term effects of pyrethroids have not been investigated. We examined the association between pyrethroid exposure and attention-deficit/hyperactivity disorder (ADHD) symptoms over time, with exposure windows spanning from the prenatal period to school-age. Methods: Using 524 mother–child pairs, we measured urinary concentrations of 3-phenoxybenzoic acid (3-PBA), a major pyrethroid metabolite, and asked parents to fill-out the ADHD Rating Scale IV (ARS). We used Poisson regression to identify the susceptible periods of pyrethroid exposure, by correlating various 3-PBA exposure windows (prenatal, ages 2, 4, 6 and 8) with ADHD symptoms at ages 6 and 8. Results: Doubling of prenatal and age 2 3-PBA concentrations was associated with increased ADHD symptoms at age 6 (2.7% change, 95% confidence interval [CI]: 0.3, 5.2; 5.2% change [95% CI: 0.5, 10.2], respectively). The 3-PBA concentrations at age 4 and age 6 were linked with ADHD symptoms at age 8 (2.7% change [95% CI: 0.3, 5.3]; 3.3% change [95% CI: 0.2, 6.4], respectively). There were no clear sex-specific patterns in association. Discussion: Both prenatal and early-childhood exposure to 3-PBA were found to be associated with ADHD symptoms. Exposure during pregnancy, and at ages 2 to 6 were found to be susceptible periods for pyrethroid neurotoxicity at ages 6 and 8. |
| first_indexed | 2024-12-20T19:18:33Z |
| format | Article |
| id | doaj.art-ae8d3bbc53284222babdacc00988bbe1 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-20T19:18:33Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-ae8d3bbc53284222babdacc00988bbe12022-12-21T19:29:03ZengElsevierEnvironment International0160-41202022-03-01161107124The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traitsKyung-Shin Lee0Youn-Hee Lim1Young Ah Lee2Choong Ho Shin3Bung-Nyun Kim4Yun-Chul Hong5Johanna Inhyang Kim6Research Institue for Public Health, National Medical Center, Seoul, Republic of KoreaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, KoreaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, KoreaDivision of Children and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, KoreaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, South Korea; Corresponding authors at: Department of Psychiatry, Hanyang University Medical Center, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea (J-I. Kim) Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, South Korea (Y-C. Hong).Department of Psychiatry, Hanyang University Medical Center, Seoul, Republic of Korea; Corresponding authors at: Department of Psychiatry, Hanyang University Medical Center, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea (J-I. Kim) Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, South Korea (Y-C. Hong).Background: Pyrethroid insecticides are commonly used in residential settings, and their use has increased rapidly. Although research has been scarce, they have been reported to be associated with impaired neurodevelopment. Moreover, susceptible exposure windows and the long-term effects of pyrethroids have not been investigated. We examined the association between pyrethroid exposure and attention-deficit/hyperactivity disorder (ADHD) symptoms over time, with exposure windows spanning from the prenatal period to school-age. Methods: Using 524 mother–child pairs, we measured urinary concentrations of 3-phenoxybenzoic acid (3-PBA), a major pyrethroid metabolite, and asked parents to fill-out the ADHD Rating Scale IV (ARS). We used Poisson regression to identify the susceptible periods of pyrethroid exposure, by correlating various 3-PBA exposure windows (prenatal, ages 2, 4, 6 and 8) with ADHD symptoms at ages 6 and 8. Results: Doubling of prenatal and age 2 3-PBA concentrations was associated with increased ADHD symptoms at age 6 (2.7% change, 95% confidence interval [CI]: 0.3, 5.2; 5.2% change [95% CI: 0.5, 10.2], respectively). The 3-PBA concentrations at age 4 and age 6 were linked with ADHD symptoms at age 8 (2.7% change [95% CI: 0.3, 5.3]; 3.3% change [95% CI: 0.2, 6.4], respectively). There were no clear sex-specific patterns in association. Discussion: Both prenatal and early-childhood exposure to 3-PBA were found to be associated with ADHD symptoms. Exposure during pregnancy, and at ages 2 to 6 were found to be susceptible periods for pyrethroid neurotoxicity at ages 6 and 8.http://www.sciencedirect.com/science/article/pii/S0160412022000502Attention-deficit/hyperactivity disorderChild developmentCohort studyCritical periodPyrethroids |
| spellingShingle | Kyung-Shin Lee Youn-Hee Lim Young Ah Lee Choong Ho Shin Bung-Nyun Kim Yun-Chul Hong Johanna Inhyang Kim The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits Environment International Attention-deficit/hyperactivity disorder Child development Cohort study Critical period Pyrethroids |
| title | The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits |
| title_full | The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits |
| title_fullStr | The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits |
| title_full_unstemmed | The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits |
| title_short | The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits |
| title_sort | association of prenatal and childhood pyrethroid pesticide exposure with school age adhd traits |
| topic | Attention-deficit/hyperactivity disorder Child development Cohort study Critical period Pyrethroids |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022000502 |
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