Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastases
We present an uncommon case of liver graft dysfunction caused by seronegative hepatitis C-related fibrosing cholestatic hepatitis after cadaver liver transplantation for unresectable liver metastases of neuroendocrine small intestine cancer followed by living relation donor liver fragment retranspla...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2020-12-01
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| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/537 |
| _version_ | 1797696849442766848 |
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| author | S. E. Voskanyan V. E. Syutkin M. V. Shabalin A. I. Artemyev I. Yu. Kolyshev A. N. Bashkov A. M. Borbat K. K. Gubarev M. V. Popov A. P. Maltseva |
| author_facet | S. E. Voskanyan V. E. Syutkin M. V. Shabalin A. I. Artemyev I. Yu. Kolyshev A. N. Bashkov A. M. Borbat K. K. Gubarev M. V. Popov A. P. Maltseva |
| author_sort | S. E. Voskanyan |
| collection | DOAJ |
| description | We present an uncommon case of liver graft dysfunction caused by seronegative hepatitis C-related fibrosing cholestatic hepatitis after cadaver liver transplantation for unresectable liver metastases of neuroendocrine small intestine cancer followed by living relation donor liver fragment retransplantation for primary graft nonfunction. Early postoperative period was complicated by hepatic artery thrombosis, cerebral hemorrhage, acute cellular rejection, bilateral polysegmental pneumonia, bleeding into neck soft tissues, severe surgical site infection, and sepsis. Anticoagulant therapy, as well as the absence of Hepatitis C Virus antibodies made difficult early diagnostics of fibrosing cholestatic hepatitis. A present-day antiviral therapy produced a complete clinical and virological response. At control examination performed at 240 days after surgery, there were neither signs of cancer progression no graft dysfunction. Liver transplantation in that case was an example of radical and effective treatment method for unresectable liver metastases of neuroendocrine small intestine cancer. Timely diagnosis and proper treatment of fibrosing cholestatic hepatitis made it possible to save the liver graft and patient's life. |
| first_indexed | 2024-03-12T03:32:05Z |
| format | Article |
| id | doaj.art-ae911eb66c924b8d89f713e408381401 |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2024-03-12T03:32:05Z |
| publishDate | 2020-12-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-ae911eb66c924b8d89f713e4083814012023-09-03T13:24:37ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092020-12-0112431933110.23873/2074-0506-2020-12-4-319-331463Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastasesS. E. Voskanyan0V. E. Syutkin1M. V. Shabalin2A. I. Artemyev3I. Yu. Kolyshev4A. N. Bashkov5A. M. Borbat6K. K. Gubarev7M. V. Popov8A. P. Maltseva9ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России; ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииWe present an uncommon case of liver graft dysfunction caused by seronegative hepatitis C-related fibrosing cholestatic hepatitis after cadaver liver transplantation for unresectable liver metastases of neuroendocrine small intestine cancer followed by living relation donor liver fragment retransplantation for primary graft nonfunction. Early postoperative period was complicated by hepatic artery thrombosis, cerebral hemorrhage, acute cellular rejection, bilateral polysegmental pneumonia, bleeding into neck soft tissues, severe surgical site infection, and sepsis. Anticoagulant therapy, as well as the absence of Hepatitis C Virus antibodies made difficult early diagnostics of fibrosing cholestatic hepatitis. A present-day antiviral therapy produced a complete clinical and virological response. At control examination performed at 240 days after surgery, there were neither signs of cancer progression no graft dysfunction. Liver transplantation in that case was an example of radical and effective treatment method for unresectable liver metastases of neuroendocrine small intestine cancer. Timely diagnosis and proper treatment of fibrosing cholestatic hepatitis made it possible to save the liver graft and patient's life.https://www.jtransplantologiya.ru/jour/article/view/537нейроэндокринный рак тонкой кишкиметастазыфиброзирующий холестатический гепатит ссеронегативный гепатит свозвратный гепатит саллотрансплантат печенидисфункциятрансплантация печениосложнения |
| spellingShingle | S. E. Voskanyan V. E. Syutkin M. V. Shabalin A. I. Artemyev I. Yu. Kolyshev A. N. Bashkov A. M. Borbat K. K. Gubarev M. V. Popov A. P. Maltseva Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastases Трансплантология (Москва) нейроэндокринный рак тонкой кишки метастазы фиброзирующий холестатический гепатит с серонегативный гепатит с возвратный гепатит с аллотрансплантат печени дисфункция трансплантация печени осложнения |
| title | Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastases |
| title_full | Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastases |
| title_fullStr | Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastases |
| title_full_unstemmed | Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastases |
| title_short | Seronegative fibrosing cholestatic hepatitis С after liver retransplantation for unresectable neuroendocrine tumor liver metastases |
| title_sort | seronegative fibrosing cholestatic hepatitis с after liver retransplantation for unresectable neuroendocrine tumor liver metastases |
| topic | нейроэндокринный рак тонкой кишки метастазы фиброзирующий холестатический гепатит с серонегативный гепатит с возвратный гепатит с аллотрансплантат печени дисфункция трансплантация печени осложнения |
| url | https://www.jtransplantologiya.ru/jour/article/view/537 |
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