Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan
This study evaluated the risks of childhood acute bronchitis and bronchiolitis (CABs) for children with asthma or allergic rhinitis (AR). Using insurance claims data of Taiwan, we identified, from children of ≤12 years old in 2000–2016, cohorts with and without asthma (N = 192,126, each) and cohorts...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/3/810 |
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| author | Fung-Chang Sung Chang-Ching Wei Chih-Hsin Muo Shan P. Tsai Chao W. Chen Dennis P. H. Hsieh Pei-Chun Chen Chung-Yen Lu |
| author_facet | Fung-Chang Sung Chang-Ching Wei Chih-Hsin Muo Shan P. Tsai Chao W. Chen Dennis P. H. Hsieh Pei-Chun Chen Chung-Yen Lu |
| author_sort | Fung-Chang Sung |
| collection | DOAJ |
| description | This study evaluated the risks of childhood acute bronchitis and bronchiolitis (CABs) for children with asthma or allergic rhinitis (AR). Using insurance claims data of Taiwan, we identified, from children of ≤12 years old in 2000–2016, cohorts with and without asthma (N = 192,126, each) and cohorts with and without AR (N = 1,062,903, each) matched by sex and age. By the end of 2016, the asthma cohort had the highest bronchitis incidence, AR and non-asthma cohorts followed, and the lowest in the non-AR cohort (525.1, 322.4, 236.0 and 169.9 per 1000 person-years, respectively). The Cox method estimated adjusted hazard ratios (aHRs) of bronchitis were 1.82 (95% confidence interval (CI), 1.80–1.83) for the asthma cohort and 1.68 (95% CI, 1.68–1.69) for the AR cohort, relative to the respective comparisons. The bronchiolitis incidence rates for these cohorts were 42.7, 29.5, 28.5 and 20.1 per 1000 person-years, respectively. The aHRs of bronchiolitis were 1.50 (95% CI, 1.48–1.52) for the asthma cohort and 1.46 (95% CI, 1.45–1.47) for the AR cohort relative to their comparisons. The CABs incidence rates decreased substantially with increasing age, but were relatively similar for boys and girls. In conclusion, children with asthma are more likely to develop CABs than are children with AR. |
| first_indexed | 2024-03-11T05:46:03Z |
| format | Article |
| id | doaj.art-ae91e49a35474d779ff707a7f6dfce95 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T05:46:03Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ae91e49a35474d779ff707a7f6dfce952023-11-17T14:24:40ZengMDPI AGViruses1999-49152023-03-0115381010.3390/v15030810Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in TaiwanFung-Chang Sung0Chang-Ching Wei1Chih-Hsin Muo2Shan P. Tsai3Chao W. Chen4Dennis P. H. Hsieh5Pei-Chun Chen6Chung-Yen Lu7Department of Health Services Administration, College of Public Health, China Medical University, Taichung 406, TaiwanDepartment of Pediatrics, College of Medicine, China Medical University, Taichung 404, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung 404, TaiwanSchool of Public Health, Texas A&M University, College Station, TX 77843, USAUniversity of Maryland Global Campus, Adelphi, MD 20783, USADepartment of Environmental Toxicology, University of California at Davis, Davis, CA 95616, USADepartment of Public Health, College of Public Health, China Medical University, Taichung 406, TaiwanDepartment of Sport and Health Management, Da-Yeh University, Changhua 515, TaiwanThis study evaluated the risks of childhood acute bronchitis and bronchiolitis (CABs) for children with asthma or allergic rhinitis (AR). Using insurance claims data of Taiwan, we identified, from children of ≤12 years old in 2000–2016, cohorts with and without asthma (N = 192,126, each) and cohorts with and without AR (N = 1,062,903, each) matched by sex and age. By the end of 2016, the asthma cohort had the highest bronchitis incidence, AR and non-asthma cohorts followed, and the lowest in the non-AR cohort (525.1, 322.4, 236.0 and 169.9 per 1000 person-years, respectively). The Cox method estimated adjusted hazard ratios (aHRs) of bronchitis were 1.82 (95% confidence interval (CI), 1.80–1.83) for the asthma cohort and 1.68 (95% CI, 1.68–1.69) for the AR cohort, relative to the respective comparisons. The bronchiolitis incidence rates for these cohorts were 42.7, 29.5, 28.5 and 20.1 per 1000 person-years, respectively. The aHRs of bronchiolitis were 1.50 (95% CI, 1.48–1.52) for the asthma cohort and 1.46 (95% CI, 1.45–1.47) for the AR cohort relative to their comparisons. The CABs incidence rates decreased substantially with increasing age, but were relatively similar for boys and girls. In conclusion, children with asthma are more likely to develop CABs than are children with AR.https://www.mdpi.com/1999-4915/15/3/810acute bronchitis and bronchiolitisallergic rhinitisasthmahuman respiratory syncytial virus |
| spellingShingle | Fung-Chang Sung Chang-Ching Wei Chih-Hsin Muo Shan P. Tsai Chao W. Chen Dennis P. H. Hsieh Pei-Chun Chen Chung-Yen Lu Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan Viruses acute bronchitis and bronchiolitis allergic rhinitis asthma human respiratory syncytial virus |
| title | Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan |
| title_full | Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan |
| title_fullStr | Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan |
| title_full_unstemmed | Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan |
| title_short | Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis: A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan |
| title_sort | acute bronchitis and bronchiolitis infection in children with asthma and allergic rhinitis a retrospective cohort study based on 5 027 486 children in taiwan |
| topic | acute bronchitis and bronchiolitis allergic rhinitis asthma human respiratory syncytial virus |
| url | https://www.mdpi.com/1999-4915/15/3/810 |
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