Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic Births
Background: Abnormal haemoglobins (Hb) and thalassaemias are some of the most frequently observed hereditary disorders in the world, but especially in the Mediterranean region where Turkey is located. Hatay province is one of the largest provinces in the region, suggested as a target area to be sele...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2013-12-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=332 |
| _version_ | 1797914901327380480 |
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| author | Ersin Nazlıcan Özlem Çelenk Bayram Kerkez Hakan Demirhindi Muhsin Akbaba Mustafa Kiremitçi |
| author_facet | Ersin Nazlıcan Özlem Çelenk Bayram Kerkez Hakan Demirhindi Muhsin Akbaba Mustafa Kiremitçi |
| author_sort | Ersin Nazlıcan |
| collection | DOAJ |
| description | Background: Abnormal haemoglobins (Hb) and thalassaemias are some of the most frequently observed hereditary disorders in the world, but especially in the Mediterranean region where Turkey is located. Hatay province is one of the largest provinces in the region, suggested as a target area to be selected for preventive programs after studies by three Turkish universities, i.e. Çukurova, Akdeniz and Hacettepe Universities in Turkey.
Aims: The aim of this study was to determine demographic and family characteristics of all haemoglobinopathy carrier married couples registered in the Hatay Provincial Health Directorate registry and to educate the target population about pregnancy, births, prenatal diagnosis and genetic counselling with the particularly emphasised scope of eliminating all haemoglobinopathic births.
Study design: Descriptive cross-sectional and intervention study.
Methods: 1065 couples both being haemoglobinopathic carriers, registered in the Hatay Provincial Health Directorate registry were investigated for socio-demographic characteristics, obstetrical status and especially for a present pregnancy, the presence of any haemoglobinopathic patients or carrier children in the family.
Results: Among women with a history of pregnancy, 47.3% reported that they had never had any prenatal testing, while 33.1% had got received testing in each of their pregnancies. The most frequent reason for not having the test was declared as unawareness of the test (66.0%), followed by economic insufficiencies (17.1%), destiny/religious reasons (9.1%) and family interference (7.8%). After a series of descriptive analyses, the results of the final binary logistic regression model constructed to find out the risk factors significantly affecting the presence of a sick child in the family were grouped as risk increasing factors like age (95%CI between 1.002 and 1.122), marriage before 1994 (95%CI=1.081-4.161), and risk decreasing factors like family willingness for screening (95%CI=0.167-0.854), rate of prenatal testing (95%CI=0.147-0.414), age at first pregnancy (95%CI=0.469-0.882); while the frequency of births was found to have no significant effect (p>0.05).
Conclusion: Besides all legal regulations and applications, time is still needed for real success against such a diffuse and congenitally transferred disease. The education of the target populations appears to be crucial. Official applications should be forced based upon present or future laws. |
| first_indexed | 2024-04-10T12:33:25Z |
| format | Article |
| id | doaj.art-ae9453f760554687972a92d0f4e0998f |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:33:25Z |
| publishDate | 2013-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-ae9453f760554687972a92d0f4e0998f2023-02-15T16:14:48ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312013-12-0130439439910.5152/balkanmedj.2013.9076Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic BirthsErsin Nazlıcan0Özlem Çelenk1Bayram Kerkez2Hakan Demirhindi3Muhsin Akbaba4Mustafa Kiremitçi5Department of Public Health, Çukurova University Faculty of Medicine, Adana, TurkeyProjects Departmant, Provincial Health Directorate, Hatay, TurkeyVice Chancellor, Antakya State Hospital, Hatay, TurkeyDepartment of Public Health, Çukurova University Faculty of Medicine, Adana, TurkeyDepartment of Public Health, Çukurova University Faculty of Medicine, Adana, TurkeyProjects Departmant, Provincial Health Directorate, Hatay, TurkeyBackground: Abnormal haemoglobins (Hb) and thalassaemias are some of the most frequently observed hereditary disorders in the world, but especially in the Mediterranean region where Turkey is located. Hatay province is one of the largest provinces in the region, suggested as a target area to be selected for preventive programs after studies by three Turkish universities, i.e. Çukurova, Akdeniz and Hacettepe Universities in Turkey. Aims: The aim of this study was to determine demographic and family characteristics of all haemoglobinopathy carrier married couples registered in the Hatay Provincial Health Directorate registry and to educate the target population about pregnancy, births, prenatal diagnosis and genetic counselling with the particularly emphasised scope of eliminating all haemoglobinopathic births. Study design: Descriptive cross-sectional and intervention study. Methods: 1065 couples both being haemoglobinopathic carriers, registered in the Hatay Provincial Health Directorate registry were investigated for socio-demographic characteristics, obstetrical status and especially for a present pregnancy, the presence of any haemoglobinopathic patients or carrier children in the family. Results: Among women with a history of pregnancy, 47.3% reported that they had never had any prenatal testing, while 33.1% had got received testing in each of their pregnancies. The most frequent reason for not having the test was declared as unawareness of the test (66.0%), followed by economic insufficiencies (17.1%), destiny/religious reasons (9.1%) and family interference (7.8%). After a series of descriptive analyses, the results of the final binary logistic regression model constructed to find out the risk factors significantly affecting the presence of a sick child in the family were grouped as risk increasing factors like age (95%CI between 1.002 and 1.122), marriage before 1994 (95%CI=1.081-4.161), and risk decreasing factors like family willingness for screening (95%CI=0.167-0.854), rate of prenatal testing (95%CI=0.147-0.414), age at first pregnancy (95%CI=0.469-0.882); while the frequency of births was found to have no significant effect (p>0.05). Conclusion: Besides all legal regulations and applications, time is still needed for real success against such a diffuse and congenitally transferred disease. The education of the target populations appears to be crucial. Official applications should be forced based upon present or future laws.http://balkanmedicaljournal.org/text.php?lang=en&id=332Haemoglobinopathiesprenatal diagnosisMediterraneanTurkeybirth |
| spellingShingle | Ersin Nazlıcan Özlem Çelenk Bayram Kerkez Hakan Demirhindi Muhsin Akbaba Mustafa Kiremitçi Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic Births Balkan Medical Journal Haemoglobinopathies prenatal diagnosis Mediterranean Turkey birth |
| title | Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic Births |
| title_full | Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic Births |
| title_fullStr | Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic Births |
| title_full_unstemmed | Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic Births |
| title_short | Evaluation of Married Haemoglobinopathic Carrier Couples for Prevention of Haemoglobinopathic Births |
| title_sort | evaluation of married haemoglobinopathic carrier couples for prevention of haemoglobinopathic births |
| topic | Haemoglobinopathies prenatal diagnosis Mediterranean Turkey birth |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=332 |
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