Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling
Background: It has been suggested that ethnicity can make a significant difference to the likelihood of thromboembolic stroke related to atrial fibrillation. Ethnic differences have been shown to alter inflammatory and haemostatic factors; however, this may all be confounded by differences in cardio...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Indian Pacing and Electrophysiology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S097262921730092X |
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| author | Carlee D. Ruediger Bobby John Sathesh Kumar Han S. Lim Geetanjali Rangnekar Kurt C. Roberts-Thomson Glenn D. Young David Chase Prashanthan Sanders Scott R. Willoughby |
| author_facet | Carlee D. Ruediger Bobby John Sathesh Kumar Han S. Lim Geetanjali Rangnekar Kurt C. Roberts-Thomson Glenn D. Young David Chase Prashanthan Sanders Scott R. Willoughby |
| author_sort | Carlee D. Ruediger |
| collection | DOAJ |
| description | Background: It has been suggested that ethnicity can make a significant difference to the likelihood of thromboembolic stroke related to atrial fibrillation. Ethnic differences have been shown to alter inflammatory and haemostatic factors; however, this may all be confounded by differences in cardiovascular risk factors between different ethnicity. The impact of different ethnicities on the thrombogenic profile is not known. The aim of this study was to investigate differences in markers of inflammation, endothelial function and tissue remodelling between Caucasian and Indian populations with supraventricular tachycardia (SVT).
Methods: Patients with structurally normal hearts undergoing catheter ablation for SVT were studied. This study included 23 Australian (Caucasian) patients from the Royal Adelaide Hospital, Adelaide, Australia and 24 Indian (Indian) patients from the Christian Medical College, Vellore, India. Blood samples were collected from the femoral vein, and right and left atria. Blood samples were analysed for the markers of endothelial function (ADMA, ET-1), inflammation (CD40L, VCAM-1, ICAM-1), and tissue remodelling (MMP-9, TIMP-1) using ELISA.
Results: The study populations were well matched for cardiovascular risk factors and the absence of structural heart disease. No difference in the echocardiographic measurements between the two ethnicities was found. In this context, there was no difference in markers of inflammation, endothelial function or tissue remodelling between the two SVT populations.
Conclusion: Caucasian and Indian populations demonstrate similar inflammatory, endothelial function or tissue remodelling profiles. This study suggests a lack of an impact of different ethnicity in these populations in terms of thrombogenic risk. |
| first_indexed | 2024-12-20T18:07:57Z |
| format | Article |
| id | doaj.art-ae9783af92994782823ccca701cefde3 |
| institution | Directory Open Access Journal |
| issn | 0972-6292 |
| language | English |
| last_indexed | 2024-12-20T18:07:57Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Pacing and Electrophysiology Journal |
| spelling | doaj.art-ae9783af92994782823ccca701cefde32022-12-21T19:30:32ZengElsevierIndian Pacing and Electrophysiology Journal0972-62922018-01-011811510.1016/j.ipej.2017.08.002Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodellingCarlee D. Ruediger0Bobby John1Sathesh Kumar2Han S. Lim3Geetanjali Rangnekar4Kurt C. Roberts-Thomson5Glenn D. Young6David Chase7Prashanthan Sanders8Scott R. Willoughby9Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, AustraliaDepartment of Cardiology, Christian Medical College, Vellore, IndiaDepartment of Cardiology, Christian Medical College, Vellore, IndiaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, AustraliaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, AustraliaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, AustraliaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, AustraliaDepartment of Cardiology, Christian Medical College, Vellore, IndiaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, AustraliaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, AustraliaBackground: It has been suggested that ethnicity can make a significant difference to the likelihood of thromboembolic stroke related to atrial fibrillation. Ethnic differences have been shown to alter inflammatory and haemostatic factors; however, this may all be confounded by differences in cardiovascular risk factors between different ethnicity. The impact of different ethnicities on the thrombogenic profile is not known. The aim of this study was to investigate differences in markers of inflammation, endothelial function and tissue remodelling between Caucasian and Indian populations with supraventricular tachycardia (SVT). Methods: Patients with structurally normal hearts undergoing catheter ablation for SVT were studied. This study included 23 Australian (Caucasian) patients from the Royal Adelaide Hospital, Adelaide, Australia and 24 Indian (Indian) patients from the Christian Medical College, Vellore, India. Blood samples were collected from the femoral vein, and right and left atria. Blood samples were analysed for the markers of endothelial function (ADMA, ET-1), inflammation (CD40L, VCAM-1, ICAM-1), and tissue remodelling (MMP-9, TIMP-1) using ELISA. Results: The study populations were well matched for cardiovascular risk factors and the absence of structural heart disease. No difference in the echocardiographic measurements between the two ethnicities was found. In this context, there was no difference in markers of inflammation, endothelial function or tissue remodelling between the two SVT populations. Conclusion: Caucasian and Indian populations demonstrate similar inflammatory, endothelial function or tissue remodelling profiles. This study suggests a lack of an impact of different ethnicity in these populations in terms of thrombogenic risk.http://www.sciencedirect.com/science/article/pii/S097262921730092XSupraventricular tachycardiaThrombogenesisEthnicityEndothelial functionInflammation |
| spellingShingle | Carlee D. Ruediger Bobby John Sathesh Kumar Han S. Lim Geetanjali Rangnekar Kurt C. Roberts-Thomson Glenn D. Young David Chase Prashanthan Sanders Scott R. Willoughby Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling Indian Pacing and Electrophysiology Journal Supraventricular tachycardia Thrombogenesis Ethnicity Endothelial function Inflammation |
| title | Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling |
| title_full | Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling |
| title_fullStr | Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling |
| title_full_unstemmed | Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling |
| title_short | Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling |
| title_sort | influence of ethnic background on left atrial markers of inflammation endothelial function and tissue remodelling |
| topic | Supraventricular tachycardia Thrombogenesis Ethnicity Endothelial function Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S097262921730092X |
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