Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells

Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells

Diabetic osteoporosis (DOP) is a chronic complication of diabetes in the skeletal system. High level of miR-340-5p may be harmful to the bone formation. In this study, the DOP model of rats was successfully established via streptozotocin (STZ) and ovariectomy (OVX) treatment. It was manifested by re...

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Bibliographic Details
Main Authors: Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang, Binhong Wen
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Bioengineered
Subjects:
mir-340-5p
osteogenic differentiation
runx2
mc3t3-e1 cells
Online Access:http://dx.doi.org/10.1080/21655979.2021.1905259

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