Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Abstract The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorphism, leading to two allelic variants (H1 and H2). Homozygosity for the more common haplotype H1 is associated with an increased risk for several tauopathies, but also fo...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Christina V. Tauber, Sigrid C. Schwarz, Thomas W. Rösler, Thomas Arzberger, Steve Gentleman, Otto Windl, Mandy Krumbiegel, André Reis, Viktoria C. Ruf, Jochen Herms, Günter U. Höglinger
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: BMC 2023-03-01
Σειρά:Acta Neuropathologica Communications
Θέματα:
Parkinson’s disease
MAPT
Tau protein
H1 and H2 haplotype
Synucleins
Postmortem human brain
Διαθέσιμο Online:https://doi.org/10.1186/s40478-023-01534-9

Διαδίκτυο

https://doi.org/10.1186/s40478-023-01534-9

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