Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Abstract The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorphism, leading to two allelic variants (H1 and H2). Homozygosity for the more common haplotype H1 is associated with an increased risk for several tauopathies, but also fo...

Повний опис

Бібліографічні деталі
Автори: Christina V. Tauber, Sigrid C. Schwarz, Thomas W. Rösler, Thomas Arzberger, Steve Gentleman, Otto Windl, Mandy Krumbiegel, André Reis, Viktoria C. Ruf, Jochen Herms, Günter U. Höglinger
Формат: Стаття
Мова:English
Опубліковано: BMC 2023-03-01
Серія:Acta Neuropathologica Communications
Предмети:
Parkinson’s disease
MAPT
Tau protein
H1 and H2 haplotype
Synucleins
Postmortem human brain
Онлайн доступ:https://doi.org/10.1186/s40478-023-01534-9

Інтернет

https://doi.org/10.1186/s40478-023-01534-9

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