Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Abstract The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorphism, leading to two allelic variants (H1 and H2). Homozygosity for the more common haplotype H1 is associated with an increased risk for several tauopathies, but also fo...

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Những tác giả chính: Christina V. Tauber, Sigrid C. Schwarz, Thomas W. Rösler, Thomas Arzberger, Steve Gentleman, Otto Windl, Mandy Krumbiegel, André Reis, Viktoria C. Ruf, Jochen Herms, Günter U. Höglinger
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: BMC 2023-03-01
Loạt:Acta Neuropathologica Communications
Những chủ đề:
Parkinson’s disease
MAPT
Tau protein
H1 and H2 haplotype
Synucleins
Postmortem human brain
Truy cập trực tuyến:https://doi.org/10.1186/s40478-023-01534-9

Internet

https://doi.org/10.1186/s40478-023-01534-9

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