Synthesis and Anticancer Evaluation of 4-Anilinoquinolinylchalcone Derivatives

Synthesis and Anticancer Evaluation of 4-Anilinoquinolinylchalcone Derivatives

A series of 4-anilinoquinolinylchalcone derivatives were synthesized and evaluated for antiproliferative activities against the growth of human cancer cell lines (Huh-7 and MDA-MB-231) and normal lung cells (MRC-5). The results exhibited low cytotoxicity against human lung cells (MRC-5). Among them,...

Full description

Bibliographic Details
Main Authors:	Cheng-Yao Yang, Min-Yu Lee, Yeh-Long Chen, Jun-Ping Shiau, Yung-Hsiang Tsai, Chia-Ning Yang, Hsueh-Wei Chang, Chih-Hua Tseng
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	International Journal of Molecular Sciences
Subjects:	4-anilinoquinolinylchalcone lapatinib cytotoxicity reactive oxygen species apoptosis
Online Access:	https://www.mdpi.com/1422-0067/24/7/6034

Similar Items

Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators
by: Yu-Tse Kao, et al.
Published: (2020-07-01)

Synergistic Inhibition of Burkitt’s Lymphoma with Combined Ibrutinib and Lapatinib Treatment
by: Chae-Eun YANG, et al.
Published: (2023-12-01)

Role of nutraceutical against exposure to pesticide residues: power of bioactive compounds
by: Mabil Sajad, et al.
Published: (2024-04-01)

Study on the biological effects of ZnO nanosheets on EBL cells
by: Mei Li, et al.
Published: (2022-10-01)

In-vitro Study of Macelignan as a Potential Anticancer Drug against Colorectal Cancer using HCT116 Cell Line
by: M Salma Kausar, et al.
Published: (2022-01-01)

Cytotoxicity Induced by Black Phosphorus Nanosheets in Vascular Endothelial Cells via Oxidative Stress and Apoptosis Activation
by: Hao Dong, et al.
Published: (2023-05-01)

Sesamol Ameliorates Renal Injury-Mediated Atherosclerosis via Inhibition of Oxidative Stress/IKKα/p53
by: Jie-Sian Wang, et al.
Published: (2021-09-01)

Potential of Copper and Copper Compounds for Anticancer Applications
by: Peng Ji, et al.
Published: (2023-02-01)

Effect of trans-sodium crocetinate on contrast-induced cytotoxicity in HEK-293 cells
by: Fatemeh Rajabian, et al.
Published: (2023-02-01)

Lapatinib’in sıçan over ve uterus dokuları üzerine olan etkilerinin ışık ve elektron mikroskobik düzeyde araştırılması
by: Hande Tokgönül, et al.
Published: (2020-09-01)

Evaluation of Inducing Apoptosis as Cell Death Mechanism by Cold Atmospheric Plasma in Cervix Cancer Cell Line (Hela)
by: Tahereh Tayebi, et al.
Published: (2020-02-01)

Citrus Carotenoid Extracts Exert Anticancer Effects through Anti-Proliferation, Oxidative Stress, and Mitochondrial-Dependent Apoptosis in MCF-7 Cells
by: Juanjuan Wei, et al.
Published: (2023-09-01)

Micafungin induced apoptosis in Candida parapsilosis independent of its susceptibility to micafungin
by: Fazal Shirazi, et al.
Published: (2015-10-01)

The Cytotoxic and Apoptotic Effects of the Brown Algae <i>Colpomenia sinuosa</i> are Mediated by the Generation of Reactive Oxygen Species
by: Reem Al Monla, et al.
Published: (2020-04-01)

Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity
by: Aruna Chhikara, et al.
Published: (2022-10-01)

Activation of PI3K/Akt mediates the protective effect of diallyl trisulfide on doxorubicin induced cardiac apoptosis
by: Su-Ying Wen, et al.
Published: (2023-01-01)

Interaction of Adenosine, Modified Using Carborane Clusters, with Ovarian Cancer Cells: A New Anticancer Approach against Chemoresistance
by: Katarzyna Bednarska-Szczepaniak, et al.
Published: (2021-07-01)

New Insights on Hemp Oil Enriched in Cannabidiol: Decarboxylation, Antioxidant Properties and In Vitro Anticancer Effect
by: Anca Roxana Petrovici, et al.
Published: (2021-05-01)

Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis
by: Li-Jane Shih, et al.
Published: (2024-02-01)

Manoalide Induces Intrinsic Apoptosis by Oxidative Stress and Mitochondrial Dysfunction in Human Osteosarcoma Cells
by: Zhi-Kang Yao, et al.
Published: (2023-07-01)

Cellular absorption of polystyrene nanoplastics with different surface functionalization and the toxicity to RAW264.7 macrophage cells
by: Jiao Chen, et al.
Published: (2023-03-01)

Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B–PKA–Caspase8/9 Pathway
by: Jing-Li Tao, et al.
Published: (2021-01-01)

ROS-generating nanoplatforms as selective and tunable therapeutic weapons against cancer
by: Federica Foglietta, et al.
Published: (2023-12-01)

Effects of silver nanoparticles of different sizes on cytotoxicity and oxygen metabolism disorders in both reproductive and respiratory system cells
by: Zapór Lidia
Published: (2016-12-01)

Scavenging Activity on Reactive Oxygen Species with Biological Relevance by Varronia curassavica
by: Gabriela Brasil Romão Veloso, et al.
Published: (2023-07-01)

Mitochondrial Pharmacotherapeutics - Advancements and Applications
by: Vyas Ganesh, et al.
Published: (2024-01-01)

Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells
by: Javier Florido, et al.
Published: (2022-08-01)

Sevoflurane-mediated modulation of oxidative myocardial injury
by: Siavash Sedghi, et al.
Published: (2023-09-01)

Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells
by: Nabil A. Alhakamy, et al.
Published: (2020-04-01)

Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
by: Seong-Yeong Heo, et al.
Published: (2023-07-01)

Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE)
by: Hsin-Yuan Chen, et al.
Published: (2021-07-01)

Garcinone E triggers apoptosis and cell cycle arrest in human colorectal cancer cells by mediating a reactive oxygen species–dependent JNK signaling pathway
by: Renkai Li, et al.
Published: (2023-06-01)

Fine Regulation of Neutrophil Oxidative Status and Apoptosis by Ceruloplasmin and Its Derivatives
by: Ekaterina A. Golenkina, et al.
Published: (2018-01-01)

Antidepressants induce toxicity in human placental BeWo cells
by: Tomohiro Nabekura, et al.
Published: (2022-01-01)

Parenteral succinate reduces levels of reactive oxygen species without changing serum caspase-3 levels in septic rats
by: Sebastián Chapela, et al.
Published: (2022-12-01)

Reactive Oxygen Species Mediate Isoalantolactone-Induced Apoptosis in Human Prostate Cancer Cells
by: Muhammad Ali, et al.
Published: (2013-08-01)

Protective Effects of Jujubosides on 6-OHDA-Induced Neurotoxicity in SH-SY5Y and SK-N-SH Cells
by: Chao-Hsuan Chen, et al.
Published: (2022-06-01)

ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens
by: Zhaofang Xi§, Shijin Yang§, Dongyang Liu, Liming Wu, Xiaodong Liu, Jing Zhao and Dingzong Guo*
Published: (2012-10-01)

Bilobalide Induces Apoptosis in 3T3-L1 Mature Adipocytes through ROS-Mediated Mitochondria Pathway
by: Su Bu, et al.
Published: (2023-09-01)

Induction of ROS-dependent apoptotic cell death by platycodin D in human prostate cancer PC3 cells
by: Yung Hyun Choi
Published: (2022-03-01)