Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy.
Background: Monocyte Chemoattractant Protein-1 (MCP-1) is an inflammatory bio-peptide which release into body circulation in specific response to retinal inflammation. The objective of the current study was to find the levels of monocyte chemoattractant protein-1 in diabetic patients with and witho...
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| Format: | Article |
| Language: | English |
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Advance Educational Institute & Research Centre
2022-02-01
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| Series: | International Journal of Endorsing Health Science Research |
| Subjects: | |
| Online Access: | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/807 |
| _version_ | 1818319770497318912 |
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| author | Shabir Ahmed Nargis Anjum Irfan Ahmed Adil Ramzan Nosheen Wasee Nuvair Zia |
| author_facet | Shabir Ahmed Nargis Anjum Irfan Ahmed Adil Ramzan Nosheen Wasee Nuvair Zia |
| author_sort | Shabir Ahmed |
| collection | DOAJ |
| description |
Background: Monocyte Chemoattractant Protein-1 (MCP-1) is an inflammatory bio-peptide which release into body circulation in specific response to retinal inflammation. The objective of the current study was to find the levels of monocyte chemoattractant protein-1 in diabetic patients with and without diabetic retinopathy and to compare the functional role of MCP-1 as a better diagnostic biomarker in the early phase of diabetic retinopathy with conventional methods.
Methodology: This case-control study was conducted at the Physiology Department of Basic Medical Science Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC)-Karachi, from April 2019 to October 2020. Total 100 participants between 40-65 years of age were separated into four groups: Group A (n=25) diabetic-patients with diabetes duration 5-7 years with no retinopathy; Group B (n=25) diabetic patient’s diabetes duration 8-10 years with mild retinopathy, Group C (n=25) diabetic patient’s diabetes duration 10-15 years with moderate retinopathy while Group D (n=25) healthy normal individuals. All study participants were gone through a detailed history and blood sugar levels, visual acuity, slit-lamp examination, and serum MCP-1 were estimated.
Results: The present study reported significantly elevated levels of MCP-1 among group-A (without retinopathy), group B (mild diabetic retinopathy), and Group- C (moderate retinopathy), while Group-D (healthy controls) had the least level of MCP-1 (p-value=0.001) that indicate the early phase of retinal inflammation. Current study has shown strong association between MCP-1 with duration of disease (r=0.885; p < 0.01), and HbA1c (r =0.71; p <0.01) in all study participants. While statistically significant and positive association and correlation were reported between MCP-1 with blood sugar parameters (fasting and random) (r = 0.876; p< 0.01) in all study participants.
Conclusion: Elevated levels of MCP-1 with the progression of early retinal inflammation diabetic retinopathy had been reported in the current study. These findings conceivably propose that MCP-1 could be an early diagnostic marker for an additional diagnostic tool for early detection of diabetic retinopathy compared with all conventional clinical findings.
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| first_indexed | 2024-12-13T10:14:24Z |
| format | Article |
| id | doaj.art-ae98a835146a4bd09eb29c7c53293c13 |
| institution | Directory Open Access Journal |
| issn | 2307-3748 2310-3841 |
| language | English |
| last_indexed | 2024-12-13T10:14:24Z |
| publishDate | 2022-02-01 |
| publisher | Advance Educational Institute & Research Centre |
| record_format | Article |
| series | International Journal of Endorsing Health Science Research |
| spelling | doaj.art-ae98a835146a4bd09eb29c7c53293c132022-12-21T23:51:21ZengAdvance Educational Institute & Research CentreInternational Journal of Endorsing Health Science Research2307-37482310-38412022-02-0194Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy.Shabir Ahmed0Nargis Anjum1Irfan Ahmed2Adil Ramzan3Nosheen Wasee4Nuvair Zia5Department of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi-Pakistan.Department of Physiology Karachi Medical and Dental College, Karachi-Pakistan.Department of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi-Pakistan.Department of Medicine, Karachi Medical and Dental College, Karachi-Pakistan.Department of Physiology Karachi Medical and Dental College, Karachi-Pakistan.Department of Medicine, Karachi Medical and Dental College, Karachi-Pakistan. Background: Monocyte Chemoattractant Protein-1 (MCP-1) is an inflammatory bio-peptide which release into body circulation in specific response to retinal inflammation. The objective of the current study was to find the levels of monocyte chemoattractant protein-1 in diabetic patients with and without diabetic retinopathy and to compare the functional role of MCP-1 as a better diagnostic biomarker in the early phase of diabetic retinopathy with conventional methods. Methodology: This case-control study was conducted at the Physiology Department of Basic Medical Science Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC)-Karachi, from April 2019 to October 2020. Total 100 participants between 40-65 years of age were separated into four groups: Group A (n=25) diabetic-patients with diabetes duration 5-7 years with no retinopathy; Group B (n=25) diabetic patient’s diabetes duration 8-10 years with mild retinopathy, Group C (n=25) diabetic patient’s diabetes duration 10-15 years with moderate retinopathy while Group D (n=25) healthy normal individuals. All study participants were gone through a detailed history and blood sugar levels, visual acuity, slit-lamp examination, and serum MCP-1 were estimated. Results: The present study reported significantly elevated levels of MCP-1 among group-A (without retinopathy), group B (mild diabetic retinopathy), and Group- C (moderate retinopathy), while Group-D (healthy controls) had the least level of MCP-1 (p-value=0.001) that indicate the early phase of retinal inflammation. Current study has shown strong association between MCP-1 with duration of disease (r=0.885; p < 0.01), and HbA1c (r =0.71; p <0.01) in all study participants. While statistically significant and positive association and correlation were reported between MCP-1 with blood sugar parameters (fasting and random) (r = 0.876; p< 0.01) in all study participants. Conclusion: Elevated levels of MCP-1 with the progression of early retinal inflammation diabetic retinopathy had been reported in the current study. These findings conceivably propose that MCP-1 could be an early diagnostic marker for an additional diagnostic tool for early detection of diabetic retinopathy compared with all conventional clinical findings. http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/807Diabetes Mellitus, Diabetic Retinopathy, Monocyte Chemoattractant Protein-1 |
| spellingShingle | Shabir Ahmed Nargis Anjum Irfan Ahmed Adil Ramzan Nosheen Wasee Nuvair Zia Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy. International Journal of Endorsing Health Science Research Diabetes Mellitus, Diabetic Retinopathy, Monocyte Chemoattractant Protein-1 |
| title | Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy. |
| title_full | Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy. |
| title_fullStr | Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy. |
| title_full_unstemmed | Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy. |
| title_short | Evaluation of Monocyte Chemoattractant Protein-1 levels as diagnostic biomarker of Diabetic Retinopathy. |
| title_sort | evaluation of monocyte chemoattractant protein 1 levels as diagnostic biomarker of diabetic retinopathy |
| topic | Diabetes Mellitus, Diabetic Retinopathy, Monocyte Chemoattractant Protein-1 |
| url | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/807 |
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