Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method.
It has been reported that 20% of early-stage oral squamous cell carcinoma (OSCC) patients treated with surgery alone (SA) may exhibit postoperative relapse within 2-3 years and have poor prognoses. We aimed to determine the safety of S-1 adjuvant chemotherapy and the potential differences in the dis...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0231656 |
| _version_ | 1819142831781969920 |
|---|---|
| author | Ryoji Yoshida Masashi Nagata Akiyuki Hirosue Kenta Kawahara Masafumi Nakamoto Masatoshi Hirayama Nozomu Takahashi Yuichiro Matsuoka Junki Sakata Hikaru Nakashima Hidetaka Arita Akimitsu Hiraki Masanori Shinohara Ken Kikuchi Hideki Nakayama |
| author_facet | Ryoji Yoshida Masashi Nagata Akiyuki Hirosue Kenta Kawahara Masafumi Nakamoto Masatoshi Hirayama Nozomu Takahashi Yuichiro Matsuoka Junki Sakata Hikaru Nakashima Hidetaka Arita Akimitsu Hiraki Masanori Shinohara Ken Kikuchi Hideki Nakayama |
| author_sort | Ryoji Yoshida |
| collection | DOAJ |
| description | It has been reported that 20% of early-stage oral squamous cell carcinoma (OSCC) patients treated with surgery alone (SA) may exhibit postoperative relapse within 2-3 years and have poor prognoses. We aimed to determine the safety of S-1 adjuvant chemotherapy and the potential differences in the disease-free survival (DFS) between patients with T2N0 (stage II) OSCC treated with S-1 adjuvant therapy (S-1) and those treated with SA. This single-center retrospective cohort study was conducted at Kumamoto University, between April 2004 and March 2012, and included 95 patients with stage II OSCC. The overall cohort (OC), and propensity score-matched cohort (PSMC) were analyzed. In the OC, 71 and 24 patients received SA and S-1, respectively. The time to relapse (TTR), DFS, and overall survival were better in the S-1 group, but the difference was not significant. In the PSMC, 20 patients each received SA and S-1. The TTR was significantly lower in the S-1 group than in the SA group, while the DFS was significantly improved in the former. S-1 adjuvant chemotherapy may be more effective than SA in early-stage OSCC. |
| first_indexed | 2024-12-22T12:16:36Z |
| format | Article |
| id | doaj.art-ae9b149e37c148ca8844fd4c794bccd9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T12:16:36Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ae9b149e37c148ca8844fd4c794bccd92022-12-21T18:26:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01154e023165610.1371/journal.pone.0231656Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method.Ryoji YoshidaMasashi NagataAkiyuki HirosueKenta KawaharaMasafumi NakamotoMasatoshi HirayamaNozomu TakahashiYuichiro MatsuokaJunki SakataHikaru NakashimaHidetaka AritaAkimitsu HirakiMasanori ShinoharaKen KikuchiHideki NakayamaIt has been reported that 20% of early-stage oral squamous cell carcinoma (OSCC) patients treated with surgery alone (SA) may exhibit postoperative relapse within 2-3 years and have poor prognoses. We aimed to determine the safety of S-1 adjuvant chemotherapy and the potential differences in the disease-free survival (DFS) between patients with T2N0 (stage II) OSCC treated with S-1 adjuvant therapy (S-1) and those treated with SA. This single-center retrospective cohort study was conducted at Kumamoto University, between April 2004 and March 2012, and included 95 patients with stage II OSCC. The overall cohort (OC), and propensity score-matched cohort (PSMC) were analyzed. In the OC, 71 and 24 patients received SA and S-1, respectively. The time to relapse (TTR), DFS, and overall survival were better in the S-1 group, but the difference was not significant. In the PSMC, 20 patients each received SA and S-1. The TTR was significantly lower in the S-1 group than in the SA group, while the DFS was significantly improved in the former. S-1 adjuvant chemotherapy may be more effective than SA in early-stage OSCC.https://doi.org/10.1371/journal.pone.0231656 |
| spellingShingle | Ryoji Yoshida Masashi Nagata Akiyuki Hirosue Kenta Kawahara Masafumi Nakamoto Masatoshi Hirayama Nozomu Takahashi Yuichiro Matsuoka Junki Sakata Hikaru Nakashima Hidetaka Arita Akimitsu Hiraki Masanori Shinohara Ken Kikuchi Hideki Nakayama Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method. PLoS ONE |
| title | Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method. |
| title_full | Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method. |
| title_fullStr | Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method. |
| title_full_unstemmed | Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method. |
| title_short | Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method. |
| title_sort | efficacy of adjuvant chemotherapy with s 1 in stage ii oral squamous cell carcinoma patients a comparative study using the propensity score matching method |
| url | https://doi.org/10.1371/journal.pone.0231656 |
| work_keys_str_mv | AT ryojiyoshida efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT masashinagata efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT akiyukihirosue efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT kentakawahara efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT masafuminakamoto efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT masatoshihirayama efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT nozomutakahashi efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT yuichiromatsuoka efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT junkisakata efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT hikarunakashima efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT hidetakaarita efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT akimitsuhiraki efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT masanorishinohara efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT kenkikuchi efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod AT hidekinakayama efficacyofadjuvantchemotherapywiths1instageiioralsquamouscellcarcinomapatientsacomparativestudyusingthepropensityscorematchingmethod |