Reactive oxygen species generation mediated by NADPH oxidase and PI3K/Akt pathways contribute to invasion of Streptococcus agalactiae in human endothelial cells

Reactive oxygen species generation mediated by NADPH oxidase and PI3K/Akt pathways contribute to invasion of Streptococcus agalactiae in human endothelial cells

BACKGROUND Streptococcus agalactiae can causes sepsis, pneumonia, and meningitis in neonates, the elderly, and immunocompromised patients. Although the virulence properties of S. agalactiae have been partially elucidated, the molecular mechanisms related to reactive oxygen species (ROS) generation i...

Full description

Bibliographic Details
Main Authors: Jessica Silva Santos de Oliveira, Gabriela da Silva Santos, João Alfredo Moraes, Alessandra Mattos Saliba, Thereza Christina Barja-Fidalgo, Ana Luíza Mattos-Guaraldi, Prescilla Emy Nagao
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2018-04-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Streptococcus agalactiae
HUVEC
reactive oxygen species
NADPH oxidase
p47phox
PI3K/Akt pathway
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000600300&lng=en&tlng=en

Similar Items

Similar Items