A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by <i>Betacoronavirus</i>

A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by <i>Betacoronavirus</i>

Exacerbated inflammatory responses are a hallmark of severe coronavirus disease 2019 (COVID-19). Zileuton (Zi) is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of several inflammatory/pro-resolving lipid mediators. Herein, we investigated the effect of Zi treatment in...

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Bibliographic Details
Main Authors: Rafaela das Dores Pereira, Rayane Aparecida Nonato Rabelo, Natália Fernanda de Melo Oliveira, Samuel Luiz Teixeira Porto, Ana Claudia dos Santos Pereira Andrade, Celso M. Queiroz-Junior, César Luís Nascimento Barbosa, Luiz Pedro de Souza-Costa, Felipe Rocha da Silva Santos, Fernando Bento Rodrigues Oliveira, Bárbara Luísa Vieira da Silva, Hanna L. Umezu, Raquel Ferreira, Glauber S. F. da Silva, Jader Santos Cruz, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Fabiana Simão Machado
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Viruses
Subjects:
zileuton
viral infection
MHV
SARS-CoV-2
COVID-19
Online Access:https://www.mdpi.com/1999-4915/15/10/2049

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