Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy
Objective To detect the changes in serum Lipids among Iraqi patients with active Rheumatoid Arthritis (RA) and the effects of drug therapy. Patients and methods Fifty Iraqi patients with untreated active Rheumatoid Arthritis and 50 matched healthy control were studied with concentration on estimatio...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2005-04-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1677 |
| _version_ | 1797368252180987904 |
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| author | Talal Abdulsa mad Ghazi T. Al-Zaidi |
| author_facet | Talal Abdulsa mad Ghazi T. Al-Zaidi |
| author_sort | Talal Abdulsa mad |
| collection | DOAJ |
| description | Objective To detect the changes in serum Lipids among Iraqi patients with active Rheumatoid Arthritis (RA) and the effects of drug therapy.
Patients and methods Fifty Iraqi patients with untreated active Rheumatoid Arthritis and 50 matched healthy control were studied with concentration on estimation of fasting serum Lipid profile which is repeated after 3month treatment with different disease modifying anti Rheumatic drugs (DMARDs) regimens.
Results Fifty Iraqi patients were included in this prospective study 47 females (94%) and 3 males (6%). The mean age of patients was (45±3.20).
fifty healthy individuals were included in this study as a control group 45 females (90%) and 5 males (10%) the mean age of the control group was (44.9±2.9).
Our results showed a significant reduction of VLDL, LDL, HDL, serum cholesterol and serum triglyceride in-patients with active RA (p=<0.05, 0.001. 0.001, 0.001 and 0.018 respectively). There was a significant relationship found between ESR and VLDL (P<0.05), serum triglyceride (P<0.04) and serum cholesterol (P<0.01). And there was a significant relationship between serum lipids and articular index VLDL (P<0.05), serum cholesterol (P<0.01) and TG (P=0.01).
After 3-months treatment with Methotrexate or Methotrexate + Chloroquine ± large dose steroid or Chloroquine alone.
There was a significant reduction of inflammatory activity and serum lipids return to levels similar to that of control group.
Conclusions:
The dyslipidemia associated with active RA characterized by low serum lipids and can be normalized by controlling disease activity with antirheumatic drugs including steroids. |
| first_indexed | 2024-03-08T17:28:59Z |
| format | Article |
| id | doaj.art-ae9c42a8debf493491b5e869bf754e68 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:28:59Z |
| publishDate | 2005-04-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-ae9c42a8debf493491b5e869bf754e682024-01-02T16:44:49ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572005-04-0147110.32007/167735-39Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug TherapyTalal Abdulsa mad0Ghazi T. Al-Zaidi1Dept. of medicine, Rheumatology unit, factuality of medicine, university of Baghdad.Dept. of medicine, Rheumatology unit, factuality of medicine, university of Baghdad.Objective To detect the changes in serum Lipids among Iraqi patients with active Rheumatoid Arthritis (RA) and the effects of drug therapy. Patients and methods Fifty Iraqi patients with untreated active Rheumatoid Arthritis and 50 matched healthy control were studied with concentration on estimation of fasting serum Lipid profile which is repeated after 3month treatment with different disease modifying anti Rheumatic drugs (DMARDs) regimens. Results Fifty Iraqi patients were included in this prospective study 47 females (94%) and 3 males (6%). The mean age of patients was (45±3.20). fifty healthy individuals were included in this study as a control group 45 females (90%) and 5 males (10%) the mean age of the control group was (44.9±2.9). Our results showed a significant reduction of VLDL, LDL, HDL, serum cholesterol and serum triglyceride in-patients with active RA (p=<0.05, 0.001. 0.001, 0.001 and 0.018 respectively). There was a significant relationship found between ESR and VLDL (P<0.05), serum triglyceride (P<0.04) and serum cholesterol (P<0.01). And there was a significant relationship between serum lipids and articular index VLDL (P<0.05), serum cholesterol (P<0.01) and TG (P=0.01). After 3-months treatment with Methotrexate or Methotrexate + Chloroquine ± large dose steroid or Chloroquine alone. There was a significant reduction of inflammatory activity and serum lipids return to levels similar to that of control group. Conclusions: The dyslipidemia associated with active RA characterized by low serum lipids and can be normalized by controlling disease activity with antirheumatic drugs including steroids.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1677Lipids |
| spellingShingle | Talal Abdulsa mad Ghazi T. Al-Zaidi Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy مجلة كلية الطب Lipids |
| title | Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy |
| title_full | Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy |
| title_fullStr | Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy |
| title_full_unstemmed | Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy |
| title_short | Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy |
| title_sort | serum lipids in patients with active rheumatoid arthritis and it s relation to drug therapy |
| topic | Lipids |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1677 |
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