Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease

Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease

BackgroundBlood–brain barrier (BBB) disruption has been noted in animal models of Parkinson’s disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking.ObjectiveTo determine alterations in BBB integrity in PD, with comparison to cerebrovascula...

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Bibliographic Details
Main Authors:	Sarah Al-Bachari, Josephine H. Naish, Geoff J. M. Parker, Hedley C. A. Emsley, Laura M. Parkes
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Physiology
Subjects:	blood–brain barrier cerebrovascular disease dynamic contrast enhanced MRI Parkinson’s disease neurovascular unit
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2020.593026/full

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