The role of oxidative damage in cataract etiopathogenesis
Background: Cataract usually occurs due to age and diabetes, but the mechanisms of cataract formation have not yet been fully elucidated. In this study, the relationship between cataract and oxidative stress was evaluated by examining the aqueous humor reflecting lens metabolism. Objective: In this...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-05-01
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| Series: | Therapeutic Advances in Ophthalmology |
| Online Access: | https://doi.org/10.1177/25158414231168813 |
| _version_ | 1797833851552137216 |
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| author | Enes Atalay Tevfik Oğurel Mehmet Kürşat Derici |
| author_facet | Enes Atalay Tevfik Oğurel Mehmet Kürşat Derici |
| author_sort | Enes Atalay |
| collection | DOAJ |
| description | Background: Cataract usually occurs due to age and diabetes, but the mechanisms of cataract formation have not yet been fully elucidated. In this study, the relationship between cataract and oxidative stress was evaluated by examining the aqueous humor reflecting lens metabolism. Objective: In this study, the effect of oxidative stress on the etiopathogenesis of cataract was investigated through the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase (ARE) levels in aqueous humor samples of patients with cataract. Design: A prospective cohort study. Methods: This study was conducted on patients who were scheduled for cataract surgery between June 2020 and March 2021. The patients were divided into four groups according to their cataract density as grades 1, 2, 3, and 4. TOS, TAS, and ARE levels of aqueous humor samples were measured spectrophotometrically, and comparisons were made between groups. Results: A total of 100 eyes of 100 patients were included in this study. TAS levels were found significantly higher in the grade 2 group compared with the grade 4 group ( p = 0.006). In addition, a significant negative correlation was present between cataract grade and TAS level ( r = −0.237; p = 0.018). There was no significant difference between diabetic and nondiabetic patients in terms of TAS, TOS, OSI, and ARE levels. Conclusion: The aqueous humor of patients with a high degree of cataract is characterized by low antioxidant capacity. Decreased antioxidant capacity has a role in cataract formation and progression. |
| first_indexed | 2024-04-09T14:30:45Z |
| format | Article |
| id | doaj.art-ae9de0f8a7fb4edb87a0d3990724c7c8 |
| institution | Directory Open Access Journal |
| issn | 2515-8414 |
| language | English |
| last_indexed | 2024-04-09T14:30:45Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Ophthalmology |
| spelling | doaj.art-ae9de0f8a7fb4edb87a0d3990724c7c82023-05-03T16:04:04ZengSAGE PublishingTherapeutic Advances in Ophthalmology2515-84142023-05-011510.1177/25158414231168813The role of oxidative damage in cataract etiopathogenesisEnes AtalayTevfik OğurelMehmet Kürşat DericiBackground: Cataract usually occurs due to age and diabetes, but the mechanisms of cataract formation have not yet been fully elucidated. In this study, the relationship between cataract and oxidative stress was evaluated by examining the aqueous humor reflecting lens metabolism. Objective: In this study, the effect of oxidative stress on the etiopathogenesis of cataract was investigated through the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase (ARE) levels in aqueous humor samples of patients with cataract. Design: A prospective cohort study. Methods: This study was conducted on patients who were scheduled for cataract surgery between June 2020 and March 2021. The patients were divided into four groups according to their cataract density as grades 1, 2, 3, and 4. TOS, TAS, and ARE levels of aqueous humor samples were measured spectrophotometrically, and comparisons were made between groups. Results: A total of 100 eyes of 100 patients were included in this study. TAS levels were found significantly higher in the grade 2 group compared with the grade 4 group ( p = 0.006). In addition, a significant negative correlation was present between cataract grade and TAS level ( r = −0.237; p = 0.018). There was no significant difference between diabetic and nondiabetic patients in terms of TAS, TOS, OSI, and ARE levels. Conclusion: The aqueous humor of patients with a high degree of cataract is characterized by low antioxidant capacity. Decreased antioxidant capacity has a role in cataract formation and progression.https://doi.org/10.1177/25158414231168813 |
| spellingShingle | Enes Atalay Tevfik Oğurel Mehmet Kürşat Derici The role of oxidative damage in cataract etiopathogenesis Therapeutic Advances in Ophthalmology |
| title | The role of oxidative damage in cataract etiopathogenesis |
| title_full | The role of oxidative damage in cataract etiopathogenesis |
| title_fullStr | The role of oxidative damage in cataract etiopathogenesis |
| title_full_unstemmed | The role of oxidative damage in cataract etiopathogenesis |
| title_short | The role of oxidative damage in cataract etiopathogenesis |
| title_sort | role of oxidative damage in cataract etiopathogenesis |
| url | https://doi.org/10.1177/25158414231168813 |
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