Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control study
Objective To evaluate blood lipid profiles in patients with coronavirus disease 2019 (COVID-19), and to explore the association with disease severity. Methods This case–control study included patients with COVID-19, referred to two medical centers in Kermanshah, Iran (between July 2020 and December...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-02-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221078699 |
| _version_ | 1818759753085485056 |
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| author | Shahab Changaripour Hosna Sarvazad Maryam Barghi Elham Sajadi Mahdi Hashempour Sadeghian Narges Eskandari Roozbahani |
| author_facet | Shahab Changaripour Hosna Sarvazad Maryam Barghi Elham Sajadi Mahdi Hashempour Sadeghian Narges Eskandari Roozbahani |
| author_sort | Shahab Changaripour |
| collection | DOAJ |
| description | Objective To evaluate blood lipid profiles in patients with coronavirus disease 2019 (COVID-19), and to explore the association with disease severity. Methods This case–control study included patients with COVID-19, referred to two medical centers in Kermanshah, Iran (between July 2020 and December 2020), and healthy controls. Lipid profiles were evaluated in patients who were grouped according to severe (intensive care unit [ICU]), or less severe (outpatient), forms of COVID-19, and in healthy controls, and were compared among the three groups. Results A total of 132 participants were included, comprising ICU ( n = 49), outpatient ( n = 48) and control ( n = 35) groups. Mean cholesterol levels were lower in the patient groups than in controls; high-density lipoprotein cholesterol (HDL-C) levels were higher in the ICU group versus outpatients, and low-density lipoprotein cholesterol (LDL-C) levels were lower in the ICU group versus outpatients. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group. Furthermore, LDL-C level was associated with disease severity (odds ratio 0.966, 95% confidence interval 0.944, 0.989). Conclusion Lipid profiles differ between severe and less severe forms of COVID-19. LDL-C level may be a useful indicator of COVID-19 severity. |
| first_indexed | 2024-12-18T06:47:44Z |
| format | Article |
| id | doaj.art-aea152b1b39140619472d2d8f77abdad |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-18T06:47:44Z |
| publishDate | 2022-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-aea152b1b39140619472d2d8f77abdad2022-12-21T21:17:27ZengSAGE PublishingJournal of International Medical Research1473-23002022-02-015010.1177/03000605221078699Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control studyShahab ChangaripourHosna SarvazadMaryam BarghiElham SajadiMahdi Hashempour SadeghianNarges Eskandari RoozbahaniObjective To evaluate blood lipid profiles in patients with coronavirus disease 2019 (COVID-19), and to explore the association with disease severity. Methods This case–control study included patients with COVID-19, referred to two medical centers in Kermanshah, Iran (between July 2020 and December 2020), and healthy controls. Lipid profiles were evaluated in patients who were grouped according to severe (intensive care unit [ICU]), or less severe (outpatient), forms of COVID-19, and in healthy controls, and were compared among the three groups. Results A total of 132 participants were included, comprising ICU ( n = 49), outpatient ( n = 48) and control ( n = 35) groups. Mean cholesterol levels were lower in the patient groups than in controls; high-density lipoprotein cholesterol (HDL-C) levels were higher in the ICU group versus outpatients, and low-density lipoprotein cholesterol (LDL-C) levels were lower in the ICU group versus outpatients. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group. Furthermore, LDL-C level was associated with disease severity (odds ratio 0.966, 95% confidence interval 0.944, 0.989). Conclusion Lipid profiles differ between severe and less severe forms of COVID-19. LDL-C level may be a useful indicator of COVID-19 severity.https://doi.org/10.1177/03000605221078699 |
| spellingShingle | Shahab Changaripour Hosna Sarvazad Maryam Barghi Elham Sajadi Mahdi Hashempour Sadeghian Narges Eskandari Roozbahani Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control study Journal of International Medical Research |
| title | Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control study |
| title_full | Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control study |
| title_fullStr | Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control study |
| title_full_unstemmed | Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control study |
| title_short | Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case–control study |
| title_sort | lipid profile changes in patients with covid 19 referred to medical centers in kermanshah iran a case control study |
| url | https://doi.org/10.1177/03000605221078699 |
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