Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer
Colorectal cancer (CRC) is one of the leading causes of cancer related death in the western world. Its successful treatment requires early detection and removal of precursor lesions as well as individualized treatment of advanced disease. During recent years, molecular imaging techniques have shown...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.835256/full |
| _version_ | 1818981980498296832 |
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| author | Maximilian J. Waldner Maximilian J. Waldner Markus F. Neurath Markus F. Neurath |
| author_facet | Maximilian J. Waldner Maximilian J. Waldner Markus F. Neurath Markus F. Neurath |
| author_sort | Maximilian J. Waldner |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the leading causes of cancer related death in the western world. Its successful treatment requires early detection and removal of precursor lesions as well as individualized treatment of advanced disease. During recent years, molecular imaging techniques have shown promising results to improve current clinical practice. For instance, molecular endoscopy resulted in higher detection rates of precursors in comparison to conventional endoscopy in preclinical and clinical studies. Molecular confocal endomicroscopy allowed a further classification of suspect lesions as well as the prediction and monitoring of the therapeutic response. In this review, we summarize recent achievements for molecular imaging of CRC in preclinical studies, initial clinical trials and the remaining challenges for future translation into clinical practice. |
| first_indexed | 2024-12-20T17:39:56Z |
| format | Article |
| id | doaj.art-aea1a06931ec4e3f9e3ec6b798ca8394 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T17:39:56Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-aea1a06931ec4e3f9e3ec6b798ca83942022-12-21T19:31:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-02-011210.3389/fonc.2022.835256835256Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal CancerMaximilian J. Waldner0Maximilian J. Waldner1Markus F. Neurath2Markus F. Neurath3Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanyDeutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanyDepartment of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanyDeutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanyColorectal cancer (CRC) is one of the leading causes of cancer related death in the western world. Its successful treatment requires early detection and removal of precursor lesions as well as individualized treatment of advanced disease. During recent years, molecular imaging techniques have shown promising results to improve current clinical practice. For instance, molecular endoscopy resulted in higher detection rates of precursors in comparison to conventional endoscopy in preclinical and clinical studies. Molecular confocal endomicroscopy allowed a further classification of suspect lesions as well as the prediction and monitoring of the therapeutic response. In this review, we summarize recent achievements for molecular imaging of CRC in preclinical studies, initial clinical trials and the remaining challenges for future translation into clinical practice.https://www.frontiersin.org/articles/10.3389/fonc.2022.835256/fullcolorectal canceradenomaendoscopymolecular imagingconfocal endomicroscopyRaman |
| spellingShingle | Maximilian J. Waldner Maximilian J. Waldner Markus F. Neurath Markus F. Neurath Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer Frontiers in Oncology colorectal cancer adenoma endoscopy molecular imaging confocal endomicroscopy Raman |
| title | Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer |
| title_full | Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer |
| title_fullStr | Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer |
| title_full_unstemmed | Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer |
| title_short | Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer |
| title_sort | molecular endoscopy for the diagnosis and therapeutic monitoring of colorectal cancer |
| topic | colorectal cancer adenoma endoscopy molecular imaging confocal endomicroscopy Raman |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.835256/full |
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