Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan
Ashraf O Oweis,1 Sameeha A Alshelleh,2 Lubna Hawasly,3 Ghalia Alsabbagh,3 Karem H Alzoubi4,5 1Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Internal Medicine, Nephrology Division, University of Jordan, Amman, Jordan;...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-04-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/acute-kidney-injury-among-hospital-admitted-covid-19-patients-a-study--peer-reviewed-fulltext-article-IJGM |
| _version_ | 1811288927364972544 |
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| author | Oweis AO Alshelleh SA Hawasly L Alsabbagh G Alzoubi KH |
| author_facet | Oweis AO Alshelleh SA Hawasly L Alsabbagh G Alzoubi KH |
| author_sort | Oweis AO |
| collection | DOAJ |
| description | Ashraf O Oweis,1 Sameeha A Alshelleh,2 Lubna Hawasly,3 Ghalia Alsabbagh,3 Karem H Alzoubi4,5 1Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Internal Medicine, Nephrology Division, University of Jordan, Amman, Jordan; 3Department of Internal Medicine, Jordan University of Science and Technology, Irbid, Jordan; 4Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, United Arab Emirates; 5Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Ashraf O Oweis, Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan, Tel +962-79-145-5505, Email aooweis@just.edu.joObjective: During the COVID-19 pandemic, many patients have been admitted to hospitals with severe respiratory disease and suffered complications. Acute kidney injury (AKI) is among the more dangerous complications contributing to morbidity and mortality among patients.Methods: This retrospective study focused on all hospital-admitted COVID-19 patients between September and December 2020. A total of 1,044 patients were enrolled. Patient demographics, medical records, and laboratory data were gathered. Patients were split into two groups: AKI and non-AKI. Comparisons comprised demographics, labs, ICU transfer, need for ventilation and oxygen therapy, medications, hospital stay, and deaths.Results: AKI incidence in the cohort was 25.3%, and a majority were stage 1 (53.3%). Among these, hemodialysis was started in 1.8%. Higher age (P< 0.001), diabetes mellitus (P=0.001), hypertension (P=0.001), ACEI/ARB use (P=0.008), erythrocyte-sedimentation rate (P=0.002), CRP (P< 0.0001), and ferritin (P=0.01) were predictors of AKI. Among all admitted COVID-19 patients, 30.2% died in hospital. Among those with AKI, 75.9% died in comparison to 24.1% of non-AKI patients (P< 0.001). Among COVID-19 patients admitted to the ICU, 80.5% died: 70.5% were from the AKI group and 29.5% from the non-AKI group (P< 0.001).Conclusion: High mortality and morbidity is associated with COVID-19 infection, and AKI is contributing significantly to the outcomes of hospitalized patients with the infection. Early recognition of and treatment for AKI will decrease mortality and hospitalization in patients with COVID-19.Keywords: acute kidney injury, COVID, mortality, dialysis |
| first_indexed | 2024-04-13T03:46:04Z |
| format | Article |
| id | doaj.art-aea22e1cab304786a8172262be1e915a |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-13T03:46:04Z |
| publishDate | 2022-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-aea22e1cab304786a8172262be1e915a2022-12-22T03:04:01ZengDove Medical PressInternational Journal of General Medicine1178-70742022-04-01Volume 154475448274905Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from JordanOweis AOAlshelleh SAHawasly LAlsabbagh GAlzoubi KHAshraf O Oweis,1 Sameeha A Alshelleh,2 Lubna Hawasly,3 Ghalia Alsabbagh,3 Karem H Alzoubi4,5 1Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Internal Medicine, Nephrology Division, University of Jordan, Amman, Jordan; 3Department of Internal Medicine, Jordan University of Science and Technology, Irbid, Jordan; 4Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, United Arab Emirates; 5Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Ashraf O Oweis, Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan, Tel +962-79-145-5505, Email aooweis@just.edu.joObjective: During the COVID-19 pandemic, many patients have been admitted to hospitals with severe respiratory disease and suffered complications. Acute kidney injury (AKI) is among the more dangerous complications contributing to morbidity and mortality among patients.Methods: This retrospective study focused on all hospital-admitted COVID-19 patients between September and December 2020. A total of 1,044 patients were enrolled. Patient demographics, medical records, and laboratory data were gathered. Patients were split into two groups: AKI and non-AKI. Comparisons comprised demographics, labs, ICU transfer, need for ventilation and oxygen therapy, medications, hospital stay, and deaths.Results: AKI incidence in the cohort was 25.3%, and a majority were stage 1 (53.3%). Among these, hemodialysis was started in 1.8%. Higher age (P< 0.001), diabetes mellitus (P=0.001), hypertension (P=0.001), ACEI/ARB use (P=0.008), erythrocyte-sedimentation rate (P=0.002), CRP (P< 0.0001), and ferritin (P=0.01) were predictors of AKI. Among all admitted COVID-19 patients, 30.2% died in hospital. Among those with AKI, 75.9% died in comparison to 24.1% of non-AKI patients (P< 0.001). Among COVID-19 patients admitted to the ICU, 80.5% died: 70.5% were from the AKI group and 29.5% from the non-AKI group (P< 0.001).Conclusion: High mortality and morbidity is associated with COVID-19 infection, and AKI is contributing significantly to the outcomes of hospitalized patients with the infection. Early recognition of and treatment for AKI will decrease mortality and hospitalization in patients with COVID-19.Keywords: acute kidney injury, COVID, mortality, dialysishttps://www.dovepress.com/acute-kidney-injury-among-hospital-admitted-covid-19-patients-a-study--peer-reviewed-fulltext-article-IJGMacute kidney injurycovidmortalitydialysis |
| spellingShingle | Oweis AO Alshelleh SA Hawasly L Alsabbagh G Alzoubi KH Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan International Journal of General Medicine acute kidney injury covid mortality dialysis |
| title | Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan |
| title_full | Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan |
| title_fullStr | Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan |
| title_full_unstemmed | Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan |
| title_short | Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan |
| title_sort | acute kidney injury among hospital admitted covid 19 patients a study from jordan |
| topic | acute kidney injury covid mortality dialysis |
| url | https://www.dovepress.com/acute-kidney-injury-among-hospital-admitted-covid-19-patients-a-study--peer-reviewed-fulltext-article-IJGM |
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