Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals
Oxidative stress has been implicated in the pathogenesis of cognitive impairment. Lead (Pb) is a common environmental toxicant and plays a vital role in oxidative stress activation. In this study, a superoxide dismutase (SOD) and catalase (CAT) containing poly (lactic-co-glycolic acid) (PLGA) meso-p...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2021-01-01
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| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201404 |
| _version_ | 1818577297307860992 |
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| author | Chao Chen Xiaoxin Zhang Hao Huang Hongyi Bao Xiaodong Li Ye Cheng Jing Zhang Yin Ding Yanguang Yang Haiying Gu Donglin Xia |
| author_facet | Chao Chen Xiaoxin Zhang Hao Huang Hongyi Bao Xiaodong Li Ye Cheng Jing Zhang Yin Ding Yanguang Yang Haiying Gu Donglin Xia |
| author_sort | Chao Chen |
| collection | DOAJ |
| description | Oxidative stress has been implicated in the pathogenesis of cognitive impairment. Lead (Pb) is a common environmental toxicant and plays a vital role in oxidative stress activation. In this study, a superoxide dismutase (SOD) and catalase (CAT) containing poly (lactic-co-glycolic acid) (PLGA) meso-particles (PLGA@SOD-CAT) were prepared to attenuate cognitive impairment via inhibiting oxidative stress in rats. It was prepared using a double emulsion (water/oil/water phase) technique to minimize the hazardous effects of Pb burden on cognitive impairment. The meso-particles antagonized the Pb-induced cognitive impairments. Behaviour, serum biochemical parameters and biomarkers of oxidative stress in rats were evaluated after they were subjected to intravenous injection with lead nitrate and PLGA@SOD-CAT. Moreover, the potential protective mechanism of PLGA@SOD-CAT was determined. Notably, PLGA@SOD-CAT appreciably agented memory impairment caused by lead nitrate and it could significantly inhibit Pb-induced oxidative stress in the blood. Furthermore, a remarkable reversion effect of cognitive impairments, including escape latency, crossing platform times and time per cent during the platform quadrant, after PLGA@SOD-CAT administration were noted. Therefore, these results suggested that the bi-enzymes platform was a superior product in eliminating Pb-induced cognitive impairments through reducing expression of Pb-associated oxidative stress, and it could potentially be applied in detoxifying heavy metals in blood circulation. |
| first_indexed | 2024-12-16T06:27:40Z |
| format | Article |
| id | doaj.art-aea2e3f8a3d642c69b7b4151be3d8fdd |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-16T06:27:40Z |
| publishDate | 2021-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-aea2e3f8a3d642c69b7b4151be3d8fdd2022-12-21T22:40:58ZengThe Royal SocietyRoyal Society Open Science2054-57032021-01-018110.1098/rsos.201404201404Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metalsChao ChenXiaoxin ZhangHao HuangHongyi BaoXiaodong LiYe ChengJing ZhangYin DingYanguang YangHaiying GuDonglin XiaOxidative stress has been implicated in the pathogenesis of cognitive impairment. Lead (Pb) is a common environmental toxicant and plays a vital role in oxidative stress activation. In this study, a superoxide dismutase (SOD) and catalase (CAT) containing poly (lactic-co-glycolic acid) (PLGA) meso-particles (PLGA@SOD-CAT) were prepared to attenuate cognitive impairment via inhibiting oxidative stress in rats. It was prepared using a double emulsion (water/oil/water phase) technique to minimize the hazardous effects of Pb burden on cognitive impairment. The meso-particles antagonized the Pb-induced cognitive impairments. Behaviour, serum biochemical parameters and biomarkers of oxidative stress in rats were evaluated after they were subjected to intravenous injection with lead nitrate and PLGA@SOD-CAT. Moreover, the potential protective mechanism of PLGA@SOD-CAT was determined. Notably, PLGA@SOD-CAT appreciably agented memory impairment caused by lead nitrate and it could significantly inhibit Pb-induced oxidative stress in the blood. Furthermore, a remarkable reversion effect of cognitive impairments, including escape latency, crossing platform times and time per cent during the platform quadrant, after PLGA@SOD-CAT administration were noted. Therefore, these results suggested that the bi-enzymes platform was a superior product in eliminating Pb-induced cognitive impairments through reducing expression of Pb-associated oxidative stress, and it could potentially be applied in detoxifying heavy metals in blood circulation.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201404cognitive impairmentsoxidative stressmorris water mazeleadbi-enzymes |
| spellingShingle | Chao Chen Xiaoxin Zhang Hao Huang Hongyi Bao Xiaodong Li Ye Cheng Jing Zhang Yin Ding Yanguang Yang Haiying Gu Donglin Xia Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals Royal Society Open Science cognitive impairments oxidative stress morris water maze lead bi-enzymes |
| title | Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals |
| title_full | Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals |
| title_fullStr | Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals |
| title_full_unstemmed | Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals |
| title_short | Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals |
| title_sort | bi enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals |
| topic | cognitive impairments oxidative stress morris water maze lead bi-enzymes |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201404 |
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