Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery

Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery

In this study a carrier-free dry powder inhalation (DPI) containing L-arginine (ARG) was developed. As such, it is proposed that ARG could be used for adjunctive treatment of cystic fibrosis and/or tuberculosis. Various processing methods were used to manufacture high-dose formulation batches consis...

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Bibliographic Details
Main Authors: Satu Lakio, David A.V. Morton, Anna P. Ralph, Pete Lambert
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Pulmonary delivery
L-arginine
Spray drying
Mechanofusion
Dry powder inhaler (DPI)
Formulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087615000616

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