Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study
Abstract Background Antidepressant use is more common in people with Parkinson’s disease (PD), but it is unknown when this difference emerges. Methods We studied the incidence of antidepressant use in six-month periods from 10 years before to 15 years after PD diagnosis in the nationwide register-ba...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-021-02145-6 |
| _version_ | 1818574333586440192 |
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| author | Eerik Hentilä Miia Tiihonen Heidi Taipale Sirpa Hartikainen Anna-Maija Tolppanen |
| author_facet | Eerik Hentilä Miia Tiihonen Heidi Taipale Sirpa Hartikainen Anna-Maija Tolppanen |
| author_sort | Eerik Hentilä |
| collection | DOAJ |
| description | Abstract Background Antidepressant use is more common in people with Parkinson’s disease (PD), but it is unknown when this difference emerges. Methods We studied the incidence of antidepressant use in six-month periods from 10 years before to 15 years after PD diagnosis in the nationwide register-based Finnish Study on Parkinson’s disease (FINPARK). This study included 20,456 community dwellers with clinically verified PD diagnosed during 1996–2015 and 140,291 matched comparison persons. Results Altogether 44.3% of people with PD initiated antidepressants, compared to 25.0% of people without PD. The difference was largest 6 months before PD diagnosis (incidence rate ratio 5.28, 95% CI 4.80–5.80; 9.02 and 1.68 initiations/100 person-years in people with and without PD, respectively). The difference emerged already 7 years before the diagnosis and remained above the comparison group for most of the study period. Conclusions Persons with PD may have symptoms that require antidepressant treatment years before and after diagnosis. The symptoms needing antidepressant treatment may be clinical signs of possible PD and they should be considered as a need to assess clinical status in person diagnosed with PD. |
| first_indexed | 2024-12-15T00:25:12Z |
| format | Article |
| id | doaj.art-aea500f85207438c9996f9db083a89ca |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-15T00:25:12Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-aea500f85207438c9996f9db083a89ca2022-12-21T22:42:11ZengBMCBMC Geriatrics1471-23182021-03-012111710.1186/s12877-021-02145-6Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort studyEerik Hentilä0Miia Tiihonen1Heidi Taipale2Sirpa Hartikainen3Anna-Maija Tolppanen4School of Pharmacy, University of Eastern FinlandSchool of Pharmacy, University of Eastern FinlandSchool of Pharmacy, University of Eastern FinlandSchool of Pharmacy, University of Eastern FinlandSchool of Pharmacy, University of Eastern FinlandAbstract Background Antidepressant use is more common in people with Parkinson’s disease (PD), but it is unknown when this difference emerges. Methods We studied the incidence of antidepressant use in six-month periods from 10 years before to 15 years after PD diagnosis in the nationwide register-based Finnish Study on Parkinson’s disease (FINPARK). This study included 20,456 community dwellers with clinically verified PD diagnosed during 1996–2015 and 140,291 matched comparison persons. Results Altogether 44.3% of people with PD initiated antidepressants, compared to 25.0% of people without PD. The difference was largest 6 months before PD diagnosis (incidence rate ratio 5.28, 95% CI 4.80–5.80; 9.02 and 1.68 initiations/100 person-years in people with and without PD, respectively). The difference emerged already 7 years before the diagnosis and remained above the comparison group for most of the study period. Conclusions Persons with PD may have symptoms that require antidepressant treatment years before and after diagnosis. The symptoms needing antidepressant treatment may be clinical signs of possible PD and they should be considered as a need to assess clinical status in person diagnosed with PD.https://doi.org/10.1186/s12877-021-02145-6Parkinson’s diseaseAntidepressantIncidenceEpidemiologyCohort studies |
| spellingShingle | Eerik Hentilä Miia Tiihonen Heidi Taipale Sirpa Hartikainen Anna-Maija Tolppanen Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study BMC Geriatrics Parkinson’s disease Antidepressant Incidence Epidemiology Cohort studies |
| title | Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study |
| title_full | Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study |
| title_fullStr | Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study |
| title_full_unstemmed | Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study |
| title_short | Incidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study |
| title_sort | incidence of antidepressant use among community dwellers with and without parkinson s disease a nationwide cohort study |
| topic | Parkinson’s disease Antidepressant Incidence Epidemiology Cohort studies |
| url | https://doi.org/10.1186/s12877-021-02145-6 |
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