The Emerging Role of EVA1A in Different Types of Cancers
Eva-1 homolog A (EVA1A), also known as transmembrane protein 166 (TMEM166) and regulator of programmed cell death, is an endoplasmic reticulum associated protein, which can play an important role in many diseases, including a variety of cancers, by regulating autophagy/apoptosis. However, the relate...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6665 |
| _version_ | 1797486450117181440 |
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| author | Huijie Zhao Huiyang Liu Yihan Yang Honggang Wang |
| author_facet | Huijie Zhao Huiyang Liu Yihan Yang Honggang Wang |
| author_sort | Huijie Zhao |
| collection | DOAJ |
| description | Eva-1 homolog A (EVA1A), also known as transmembrane protein 166 (TMEM166) and regulator of programmed cell death, is an endoplasmic reticulum associated protein, which can play an important role in many diseases, including a variety of cancers, by regulating autophagy/apoptosis. However, the related mechanism, especially the role of EVA1A in cancers, has not been fully understood. In this review, we summarize the recent studies on the role of EVA1A in different types of cancers, including breast cancer, papillary thyroid cancer, non-small cell lung cancer, hepatocellular carcinoma, glioblastoma and pancreatic cancer, and analyze the relevant mechanisms to provide a theoretical basis for future related research. |
| first_indexed | 2024-03-09T23:34:22Z |
| format | Article |
| id | doaj.art-aea5760afabc4954b421278171ef03cb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:34:22Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-aea5760afabc4954b421278171ef03cb2023-11-23T17:04:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312666510.3390/ijms23126665The Emerging Role of EVA1A in Different Types of CancersHuijie Zhao0Huiyang Liu1Yihan Yang2Honggang Wang3Institute of Chronic Disease Risks Assessment, Henan University, Jinming Avenue, Kaifeng 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaEva-1 homolog A (EVA1A), also known as transmembrane protein 166 (TMEM166) and regulator of programmed cell death, is an endoplasmic reticulum associated protein, which can play an important role in many diseases, including a variety of cancers, by regulating autophagy/apoptosis. However, the related mechanism, especially the role of EVA1A in cancers, has not been fully understood. In this review, we summarize the recent studies on the role of EVA1A in different types of cancers, including breast cancer, papillary thyroid cancer, non-small cell lung cancer, hepatocellular carcinoma, glioblastoma and pancreatic cancer, and analyze the relevant mechanisms to provide a theoretical basis for future related research.https://www.mdpi.com/1422-0067/23/12/6665EVA1Aautophagytriple-negative breast cancerpapillary thyroid cancernon-small cell lung cancerhepatocellular carcinoma |
| spellingShingle | Huijie Zhao Huiyang Liu Yihan Yang Honggang Wang The Emerging Role of EVA1A in Different Types of Cancers International Journal of Molecular Sciences EVA1A autophagy triple-negative breast cancer papillary thyroid cancer non-small cell lung cancer hepatocellular carcinoma |
| title | The Emerging Role of EVA1A in Different Types of Cancers |
| title_full | The Emerging Role of EVA1A in Different Types of Cancers |
| title_fullStr | The Emerging Role of EVA1A in Different Types of Cancers |
| title_full_unstemmed | The Emerging Role of EVA1A in Different Types of Cancers |
| title_short | The Emerging Role of EVA1A in Different Types of Cancers |
| title_sort | emerging role of eva1a in different types of cancers |
| topic | EVA1A autophagy triple-negative breast cancer papillary thyroid cancer non-small cell lung cancer hepatocellular carcinoma |
| url | https://www.mdpi.com/1422-0067/23/12/6665 |
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