Perspectives in Genome-Editing Techniques for Livestock
Genome editing of farm animals has undeniable practical applications. It helps to improve production traits, enhances the economic value of livestock, and increases disease resistance. Gene-modified animals are also used for biomedical research and drug production and demonstrate the potential to be...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/16/2580 |
| _version_ | 1827730659155640320 |
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| author | Julia Popova Victoria Bets Elena Kozhevnikova |
| author_facet | Julia Popova Victoria Bets Elena Kozhevnikova |
| author_sort | Julia Popova |
| collection | DOAJ |
| description | Genome editing of farm animals has undeniable practical applications. It helps to improve production traits, enhances the economic value of livestock, and increases disease resistance. Gene-modified animals are also used for biomedical research and drug production and demonstrate the potential to be used as xenograft donors for humans. The recent discovery of site-specific nucleases that allow precision genome editing of a single-cell embryo (or embryonic stem cells) and the development of new embryological delivery manipulations have revolutionized the transgenesis field. These relatively new approaches have already proven to be efficient and reliable for genome engineering and have wide potential for use in agriculture. A number of advanced methodologies have been tested in laboratory models and might be considered for application in livestock animals. At the same time, these methods must meet the requirements of safety, efficiency and availability of their application for a wide range of farm animals. This review aims at covering a brief history of livestock animal genome engineering and outlines possible future directions to design optimal and cost-effective tools for transgenesis in farm species. |
| first_indexed | 2024-03-11T00:11:46Z |
| format | Article |
| id | doaj.art-aea669761cb3499983edb2e108b57627 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T00:11:46Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-aea669761cb3499983edb2e108b576272023-11-18T23:57:14ZengMDPI AGAnimals2076-26152023-08-011316258010.3390/ani13162580Perspectives in Genome-Editing Techniques for LivestockJulia Popova0Victoria Bets1Elena Kozhevnikova2Laboratory of Bioengineering, Novosibirsk State Agrarian University, 630039 Novosibirsk, RussiaLaboratory of Bioengineering, Novosibirsk State Agrarian University, 630039 Novosibirsk, RussiaLaboratory of Bioengineering, Novosibirsk State Agrarian University, 630039 Novosibirsk, RussiaGenome editing of farm animals has undeniable practical applications. It helps to improve production traits, enhances the economic value of livestock, and increases disease resistance. Gene-modified animals are also used for biomedical research and drug production and demonstrate the potential to be used as xenograft donors for humans. The recent discovery of site-specific nucleases that allow precision genome editing of a single-cell embryo (or embryonic stem cells) and the development of new embryological delivery manipulations have revolutionized the transgenesis field. These relatively new approaches have already proven to be efficient and reliable for genome engineering and have wide potential for use in agriculture. A number of advanced methodologies have been tested in laboratory models and might be considered for application in livestock animals. At the same time, these methods must meet the requirements of safety, efficiency and availability of their application for a wide range of farm animals. This review aims at covering a brief history of livestock animal genome engineering and outlines possible future directions to design optimal and cost-effective tools for transgenesis in farm species.https://www.mdpi.com/2076-2615/13/16/2580genome editinglivestockCRISPR/Cas9 |
| spellingShingle | Julia Popova Victoria Bets Elena Kozhevnikova Perspectives in Genome-Editing Techniques for Livestock Animals genome editing livestock CRISPR/Cas9 |
| title | Perspectives in Genome-Editing Techniques for Livestock |
| title_full | Perspectives in Genome-Editing Techniques for Livestock |
| title_fullStr | Perspectives in Genome-Editing Techniques for Livestock |
| title_full_unstemmed | Perspectives in Genome-Editing Techniques for Livestock |
| title_short | Perspectives in Genome-Editing Techniques for Livestock |
| title_sort | perspectives in genome editing techniques for livestock |
| topic | genome editing livestock CRISPR/Cas9 |
| url | https://www.mdpi.com/2076-2615/13/16/2580 |
| work_keys_str_mv | AT juliapopova perspectivesingenomeeditingtechniquesforlivestock AT victoriabets perspectivesingenomeeditingtechniquesforlivestock AT elenakozhevnikova perspectivesingenomeeditingtechniquesforlivestock |