Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels
Accumulating evidence has suggested the significant potential of chemically modified hydrogels in bone regeneration. Despite the progress of bioactive hydrogels with different materials, structures and loading cargoes, the desires from clinical applications have not been fully validated. Multiple bi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/7/4/199 |
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| author | Weikai Chen Ziyang Zhou Dagui Chen Yinghua Li Qin Zhang Jiacan Su |
| author_facet | Weikai Chen Ziyang Zhou Dagui Chen Yinghua Li Qin Zhang Jiacan Su |
| author_sort | Weikai Chen |
| collection | DOAJ |
| description | Accumulating evidence has suggested the significant potential of chemically modified hydrogels in bone regeneration. Despite the progress of bioactive hydrogels with different materials, structures and loading cargoes, the desires from clinical applications have not been fully validated. Multiple biological behaviors are orchestrated precisely during the bone regeneration process, including bone marrow mesenchymal stem cells (BMSCs) recruitment, osteogenic differentiation, matrix calcification and well-organized remodeling. Since matrix metalloproteinases play critical roles in such bone metabolism processes as BMSC commitment, osteoblast survival, osteoclast activation matrix calcification and microstructure remodeling, matrix metalloproteinase (MMP) cleavable peptides-based hydrogels could respond to various MMP levels and, thus, accelerate bone regeneration. In this review, we focused on the MMP-cleavable peptides, polymers, functional modification and crosslinked reactions. Applications, perspectives and limitations of MMP-cleavable peptides-based hydrogels for bone regeneration were then discussed. |
| first_indexed | 2024-03-10T04:03:33Z |
| format | Article |
| id | doaj.art-aea98cfa771946ce86878d6a8c7232e1 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T04:03:33Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-aea98cfa771946ce86878d6a8c7232e12023-11-23T08:27:52ZengMDPI AGGels2310-28612021-11-017419910.3390/gels7040199Bone Regeneration Using MMP-Cleavable Peptides-Based HydrogelsWeikai Chen0Ziyang Zhou1Dagui Chen2Yinghua Li3Qin Zhang4Jiacan Su5Institute of Translational Medicine, Shanghai University, Shanghai 200444, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai 200444, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai 200444, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai 200444, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai 200444, ChinaDepartment of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai 200433, ChinaAccumulating evidence has suggested the significant potential of chemically modified hydrogels in bone regeneration. Despite the progress of bioactive hydrogels with different materials, structures and loading cargoes, the desires from clinical applications have not been fully validated. Multiple biological behaviors are orchestrated precisely during the bone regeneration process, including bone marrow mesenchymal stem cells (BMSCs) recruitment, osteogenic differentiation, matrix calcification and well-organized remodeling. Since matrix metalloproteinases play critical roles in such bone metabolism processes as BMSC commitment, osteoblast survival, osteoclast activation matrix calcification and microstructure remodeling, matrix metalloproteinase (MMP) cleavable peptides-based hydrogels could respond to various MMP levels and, thus, accelerate bone regeneration. In this review, we focused on the MMP-cleavable peptides, polymers, functional modification and crosslinked reactions. Applications, perspectives and limitations of MMP-cleavable peptides-based hydrogels for bone regeneration were then discussed.https://www.mdpi.com/2310-2861/7/4/199MMP-cleavable peptidescrosslinkinghydrogelsdegradationbone regeneration |
| spellingShingle | Weikai Chen Ziyang Zhou Dagui Chen Yinghua Li Qin Zhang Jiacan Su Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels Gels MMP-cleavable peptides crosslinking hydrogels degradation bone regeneration |
| title | Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels |
| title_full | Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels |
| title_fullStr | Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels |
| title_full_unstemmed | Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels |
| title_short | Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels |
| title_sort | bone regeneration using mmp cleavable peptides based hydrogels |
| topic | MMP-cleavable peptides crosslinking hydrogels degradation bone regeneration |
| url | https://www.mdpi.com/2310-2861/7/4/199 |
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