Orexin-A Regulates Follicular Growth, Proliferation, Cell Cycle and Apoptosis in Mouse Primary Granulosa Cells via the AKT/ERK Signaling Pathway

Orexin-A Regulates Follicular Growth, Proliferation, Cell Cycle and Apoptosis in Mouse Primary Granulosa Cells via the AKT/ERK Signaling Pathway

Granulosa cells (GCs) are essential for follicular growth, development, and atresia. The orexin-A (OXA) neuropeptide is widely involved in the regulation of various biological functions. OXA selectively binds to orexin receptor type 1 (OX1R) and mediates all its biological actions via OX1R. This stu...

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Bibliographic Details
Main Authors: Muhammad Safdar, Aixin Liang, Shahid Ali Rajput, Nasir Abbas, Muhammad Zubair, Aftab Shaukat, Aziz ur Rehman, Huma Jamil, Yan Guo, Farman Ullah, Liguo Yang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
orexin
granulosa cells
proliferation
apoptosis
cell cycle
AKT/ERK1/2 pathway
Online Access:https://www.mdpi.com/1420-3049/26/18/5635

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