The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase Antibodies
Objective: Detection the presumptive prevalence of silent celiac disease in patients with type 1 diabetes mellitus with determination of which gender more likely to be affected. Methods: One hundred twenty asymptomatic patients [75 male , 45 female] with type 1 diabetes mellitus with mean age ± SD...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2012-06-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/628 |
| _version_ | 1798002097358110720 |
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| author | Anower Tuama Obaid Rushdi A.H. Kubba Zaidan K .Al Hergani |
| author_facet | Anower Tuama Obaid Rushdi A.H. Kubba Zaidan K .Al Hergani |
| author_sort | Anower Tuama Obaid |
| collection | DOAJ |
| description |
Objective: Detection the presumptive prevalence of
silent celiac disease in patients with type 1 diabetes
mellitus with determination of which gender more
likely to be affected.
Methods: One hundred twenty asymptomatic patients
[75 male , 45 female] with type 1 diabetes mellitus
with mean age ± SD of 11.25 ± 2.85 year where
included in the study . All subjects were serologically
screened for the presence of anti-tissue transglutaminase
IgA antibodies (anti-tTG antibodies) by Enzyme-
Linked Immunosorbent Assay (ELISA) & total IgA
was also measured for all using radial
immunodiffusion plate . Anti-tissue transglutaminase
IgG was selectively done for patients who were
expressing negative anti-tissue transglutaminase IgA
with low total IgA levels & results were compared
to that obtained from healthy 60 persons with mean
age ± SD for them was 15.25 ± 3.85 year .
Results : Fourteen out of one hundred twenty (11.66
% ) diabetic patients had expressed positivity to antitissue
transglutaminase IgA compared to 1/60 ( 1.66
%) of non diabetic patients who had expressed such
positivity , P value equals to 0.0221 & it is
considered to be statistically significant. Three out of
one hundred twenty (2.5 % ) diabetic patients had
expressed total IgA deficiency whereas all of non
diabetic patients were expressing total IgA within
the normal range , P value equals to 0.55 & it is
considered to be not statistically significant. All of
three diabetic patients with total IgA deficiency were
not showing positivity to anti-tissue transglutaminase
IgG . Six mals & Eight female of those with type 1
diabetes mellitus had expressed positivity to anti-tissue
transglutaminase IgA , P value equals to 0.1426 &
it is considered to be not statistically significant .
Conclusion : There is an increased prevalence of IgA antitissue transglutaminase antibodies ( 11.66 % ) in children & adolescent with type 1 diabetes mellitus in comparison with control group.
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| first_indexed | 2024-04-11T11:46:54Z |
| format | Article |
| id | doaj.art-aeabdd3c9c9344a795b452d925a508b6 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-11T11:46:54Z |
| publishDate | 2012-06-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-aeabdd3c9c9344a795b452d925a508b62022-12-22T04:25:32ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652012-06-0181The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase AntibodiesAnower Tuama Obaid0Rushdi A.H. Kubba1Zaidan K .Al Hergani2Alkindy teaching hospital .Consultant physician in Alkindy teaching hospitalProfessor of medicine in Alkindy College of Medicine University of Baghdad Objective: Detection the presumptive prevalence of silent celiac disease in patients with type 1 diabetes mellitus with determination of which gender more likely to be affected. Methods: One hundred twenty asymptomatic patients [75 male , 45 female] with type 1 diabetes mellitus with mean age ± SD of 11.25 ± 2.85 year where included in the study . All subjects were serologically screened for the presence of anti-tissue transglutaminase IgA antibodies (anti-tTG antibodies) by Enzyme- Linked Immunosorbent Assay (ELISA) & total IgA was also measured for all using radial immunodiffusion plate . Anti-tissue transglutaminase IgG was selectively done for patients who were expressing negative anti-tissue transglutaminase IgA with low total IgA levels & results were compared to that obtained from healthy 60 persons with mean age ± SD for them was 15.25 ± 3.85 year . Results : Fourteen out of one hundred twenty (11.66 % ) diabetic patients had expressed positivity to antitissue transglutaminase IgA compared to 1/60 ( 1.66 %) of non diabetic patients who had expressed such positivity , P value equals to 0.0221 & it is considered to be statistically significant. Three out of one hundred twenty (2.5 % ) diabetic patients had expressed total IgA deficiency whereas all of non diabetic patients were expressing total IgA within the normal range , P value equals to 0.55 & it is considered to be not statistically significant. All of three diabetic patients with total IgA deficiency were not showing positivity to anti-tissue transglutaminase IgG . Six mals & Eight female of those with type 1 diabetes mellitus had expressed positivity to anti-tissue transglutaminase IgA , P value equals to 0.1426 & it is considered to be not statistically significant . Conclusion : There is an increased prevalence of IgA antitissue transglutaminase antibodies ( 11.66 % ) in children & adolescent with type 1 diabetes mellitus in comparison with control group. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/628DiabetesCeliac diseaseTransglutaminase |
| spellingShingle | Anower Tuama Obaid Rushdi A.H. Kubba Zaidan K .Al Hergani The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase Antibodies مجله كليه طب الكندي Diabetes Celiac disease Transglutaminase |
| title | The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase Antibodies |
| title_full | The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase Antibodies |
| title_fullStr | The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase Antibodies |
| title_full_unstemmed | The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase Antibodies |
| title_short | The Detection of Silent Celiac Disease In patients With Type 1 Diabetes Mellitus by the use of Anti Tissue Transglutaminase Antibodies |
| title_sort | detection of silent celiac disease in patients with type 1 diabetes mellitus by the use of anti tissue transglutaminase antibodies |
| topic | Diabetes Celiac disease Transglutaminase |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/628 |
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