Prion pathogenesis in the absence of NLRP3/ASC inflammasomes.

Prion pathogenesis in the absence of NLRP3/ASC inflammasomes.

The accumulation of the scrapie prion protein PrPSc, a misfolded conformer of the cellular prion protein PrPC, is a crucial feature of prion diseases. In the central nervous system, this process is accompanied by conspicuous microglia activation. The NLRP3 inflammasome is a multi-molecular complex w...

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Bibliographic Details
Main Authors: Mario Nuvolone, Silvia Sorce, Petra Schwarz, Adriano Aguzzi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4324825?pdf=render

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