A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis
Background Recently, the role of using hydrolyzed formula for the prevention of allergic disease has been questioned. However, not all hydrolyzed formulas are equal. The efficacy of each hydrolyzed formula should be established separately. We updated evidence on the effectiveness of using partially...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119300262 |
| _version_ | 1811310315384602624 |
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| author | Hania Szajewska Andrea Horvath |
| author_facet | Hania Szajewska Andrea Horvath |
| author_sort | Hania Szajewska |
| collection | DOAJ |
| description | Background Recently, the role of using hydrolyzed formula for the prevention of allergic disease has been questioned. However, not all hydrolyzed formulas are equal. The efficacy of each hydrolyzed formula should be established separately. We updated evidence on the effectiveness of using partially hydrolyzed 100% whey formula (pHF), manufactured by a single manufacturer, for reducing the risk of eczema and allergy in healthy infants at high risk for allergy.Methods The Cochrane Library, MEDLINE, and EMBASE databases were searched in June 2016 for randomized and quasi-randomized controlled trials (RCTs); additional data were obtained from reviewed articles and the authors of included trials.Results Thirteen publications reporting on eight RCTs were included. Use of pHF compared to cow’s milk formula reduced the risk of eczema and all allergic diseases among children at high risk for allergy. Both intention-to-treat analyses and per-protocol analyses showed that the reduction was statistically significant at some, albeit not all, time points.Conclusions There is evidence to consider use of pHF as an option for reducing the risk of any allergic diseases, particularly eczema. However, the certainty of the evidence is low. One characteristic that makes our meta-analysis distinct from other reviews is that it focuses exclusively on only one type of pHF. Keywords: RCT, Children, Prevention, Allergy, Protein hydrolysates |
| first_indexed | 2024-04-13T09:56:58Z |
| format | Article |
| id | doaj.art-aeac8ed92c9f4a68b401bfc7455b355f |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-13T09:56:58Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-aeac8ed92c9f4a68b401bfc7455b355f2022-12-22T02:51:22ZengElsevierWorld Allergy Organization Journal1939-45512017-01-01101A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysisHania Szajewska0Andrea Horvath1Department of Paediatrics, The Medical University of Warsaw, Żwirki i Wigury 63A, 02-091, Warsaw, Poland; Correspondence:Department of Paediatrics, The Medical University of Warsaw, Żwirki i Wigury 63A, 02-091, Warsaw, PolandBackground Recently, the role of using hydrolyzed formula for the prevention of allergic disease has been questioned. However, not all hydrolyzed formulas are equal. The efficacy of each hydrolyzed formula should be established separately. We updated evidence on the effectiveness of using partially hydrolyzed 100% whey formula (pHF), manufactured by a single manufacturer, for reducing the risk of eczema and allergy in healthy infants at high risk for allergy.Methods The Cochrane Library, MEDLINE, and EMBASE databases were searched in June 2016 for randomized and quasi-randomized controlled trials (RCTs); additional data were obtained from reviewed articles and the authors of included trials.Results Thirteen publications reporting on eight RCTs were included. Use of pHF compared to cow’s milk formula reduced the risk of eczema and all allergic diseases among children at high risk for allergy. Both intention-to-treat analyses and per-protocol analyses showed that the reduction was statistically significant at some, albeit not all, time points.Conclusions There is evidence to consider use of pHF as an option for reducing the risk of any allergic diseases, particularly eczema. However, the certainty of the evidence is low. One characteristic that makes our meta-analysis distinct from other reviews is that it focuses exclusively on only one type of pHF. Keywords: RCT, Children, Prevention, Allergy, Protein hydrolysateshttp://www.sciencedirect.com/science/article/pii/S1939455119300262 |
| spellingShingle | Hania Szajewska Andrea Horvath A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis World Allergy Organization Journal |
| title | A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis |
| title_full | A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis |
| title_fullStr | A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis |
| title_full_unstemmed | A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis |
| title_short | A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis |
| title_sort | partially hydrolyzed 100 whey formula and the risk of eczema and any allergy an updated meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1939455119300262 |
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