Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma
Abstract Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL;...
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| Format: | Article |
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Nature Portfolio
2017-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-05116-3 |
| _version_ | 1818977743229943808 |
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| author | Thomas F. E. Barth Johann M. Kraus Ludwig Lausser Lucia Flossbach Lukas Schulte Karlheinz Holzmann Hans A. Kestler Peter Möller |
| author_facet | Thomas F. E. Barth Johann M. Kraus Ludwig Lausser Lucia Flossbach Lukas Schulte Karlheinz Holzmann Hans A. Kestler Peter Möller |
| author_sort | Thomas F. E. Barth |
| collection | DOAJ |
| description | Abstract Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell MZBL - among them 9 with coexisting small cell component) and 6 DLBCL (3 activated B-cell like (ABC), 3 germinal center-like (GCB)) reveals a distinct pattern. The distinctiveness of large cell MZBL samples is further confirmed by a cohort of 270 available B-cell lymphoma and B-cell in silico profiles. Of the NF-κB genes analyzed, c-REL was overexpressed in g.i. MZBL. c-REL amplification was limited to 6/22 large cell MZBL including the large cell component of 2/9 composite small cell/large cell lymphomas, and c-Rel protein expression was found in the large cell compartment of composite lymphomas. Classification experiments on DLBCL and large cell MZBL profiles support the concept that the large cell MZBL is a distinct type of B-cell lymphoma. |
| first_indexed | 2024-12-20T16:32:35Z |
| format | Article |
| id | doaj.art-aeb0042fc4ca4e78b7d15c3d5f7ca3ca |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T16:32:35Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-aeb0042fc4ca4e78b7d15c3d5f7ca3ca2022-12-21T19:33:13ZengNature PortfolioScientific Reports2045-23222017-07-01711810.1038/s41598-017-05116-3Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphomaThomas F. E. Barth0Johann M. Kraus1Ludwig Lausser2Lucia Flossbach3Lukas Schulte4Karlheinz Holzmann5Hans A. Kestler6Peter Möller7Institute of Pathology, Ulm UniversityInstitute of Medical Systems Biology, Ulm UniversityInstitute of Medical Systems Biology, Ulm UniversityInstitute of Pathology, Ulm UniversityInstitute of Pathology, Ulm UniversityCore Unit Genomics, Ulm UniversityInstitute of Medical Systems Biology, Ulm UniversityInstitute of Pathology, Ulm UniversityAbstract Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell MZBL - among them 9 with coexisting small cell component) and 6 DLBCL (3 activated B-cell like (ABC), 3 germinal center-like (GCB)) reveals a distinct pattern. The distinctiveness of large cell MZBL samples is further confirmed by a cohort of 270 available B-cell lymphoma and B-cell in silico profiles. Of the NF-κB genes analyzed, c-REL was overexpressed in g.i. MZBL. c-REL amplification was limited to 6/22 large cell MZBL including the large cell component of 2/9 composite small cell/large cell lymphomas, and c-Rel protein expression was found in the large cell compartment of composite lymphomas. Classification experiments on DLBCL and large cell MZBL profiles support the concept that the large cell MZBL is a distinct type of B-cell lymphoma.https://doi.org/10.1038/s41598-017-05116-3 |
| spellingShingle | Thomas F. E. Barth Johann M. Kraus Ludwig Lausser Lucia Flossbach Lukas Schulte Karlheinz Holzmann Hans A. Kestler Peter Möller Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma Scientific Reports |
| title | Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma |
| title_full | Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma |
| title_fullStr | Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma |
| title_full_unstemmed | Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma |
| title_short | Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma |
| title_sort | comparative gene expression profiling of the large cell variant of gastrointestinal marginal zone b cell lymphoma |
| url | https://doi.org/10.1038/s41598-017-05116-3 |
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