The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in Mice
Background: Nowadays herbal therapy for pain relevance is the matter of considerable propensity. Artemisia sieberi Besser is one of the herbal medication which has been consider as a pain reliever in Iranian traditional medicine, which needs further scientific investigations. Objective: In this stud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2011-12-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-181-en.html |
| _version_ | 1819107330401239040 |
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| author | A Morshedi MH Dashti - R M Dehghan - H MA Bagherinasab AS Salami |
| author_facet | A Morshedi MH Dashti - R M Dehghan - H MA Bagherinasab AS Salami |
| author_sort | A Morshedi |
| collection | DOAJ |
| description | Background: Nowadays herbal therapy for pain relevance is the matter of considerable propensity. Artemisia sieberi Besser is one of the herbal medication which has been consider as a pain reliever in Iranian traditional medicine, which needs further scientific investigations. Objective: In this study the antinociceptive effect of hydro alcoholic Artemisia sieberi Besser extract (AE) was assessed by using formalin test in mice. Methods: 42 male mice were divided into 7 groups. Interaperitoneal administration of distilled water to control group, vehicle to negative sham group, 1, 2 mg/kg morphine to positive sham groups and 40, 400, and 4000 mg/kg AE to test groups were performed. 25 µl of 2% formalin was then injected into the plantar surface of animalchr('39')s hind limb and the animalchr('39')s pain behavior for one hour was assessed. Mean pain scores in each five minute time block calculated for each animal were statistically analyzed. Results: in acute phase mean pain score animals receiving 4000 mg/kg AE was significantly less than control groups p<0.05. the antinociceptive effect of AE was more prominent in the chronic phase so the analgesic effect of 4000 mg/kg AE was significantly more than 2 mg/kg. Conclusion: the data collected from this study indicates the analgesic effect of AE which is more significant in chronic phase and this effect may be due to anti-inflammatory ingredients in AE which needs to be more investigated. |
| first_indexed | 2024-12-22T02:52:19Z |
| format | Article |
| id | doaj.art-aeb21d0102b94f1181ecddaa8dfab184 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-22T02:52:19Z |
| publishDate | 2011-12-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-aeb21d0102b94f1181ecddaa8dfab1842022-12-21T18:41:21ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582011-12-0110404857The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in MiceA Morshedi0MH Dashti - R1M Dehghan - H2MA Bagherinasab3AS Salami4 Department of Physiology, Shahid Sadoughi University of Medical Sciences Department of Physiology, Shahid Sadoughi University of Medical Sciences Department of Physiology, Shahid Sadoughi University of Medical Sciences Department of Physiology, Shahid Sadoughi University of Medical Sciences Department of Physiology, Shahid Sadoughi University of Medical Sciences Background: Nowadays herbal therapy for pain relevance is the matter of considerable propensity. Artemisia sieberi Besser is one of the herbal medication which has been consider as a pain reliever in Iranian traditional medicine, which needs further scientific investigations. Objective: In this study the antinociceptive effect of hydro alcoholic Artemisia sieberi Besser extract (AE) was assessed by using formalin test in mice. Methods: 42 male mice were divided into 7 groups. Interaperitoneal administration of distilled water to control group, vehicle to negative sham group, 1, 2 mg/kg morphine to positive sham groups and 40, 400, and 4000 mg/kg AE to test groups were performed. 25 µl of 2% formalin was then injected into the plantar surface of animalchr('39')s hind limb and the animalchr('39')s pain behavior for one hour was assessed. Mean pain scores in each five minute time block calculated for each animal were statistically analyzed. Results: in acute phase mean pain score animals receiving 4000 mg/kg AE was significantly less than control groups p<0.05. the antinociceptive effect of AE was more prominent in the chronic phase so the analgesic effect of 4000 mg/kg AE was significantly more than 2 mg/kg. Conclusion: the data collected from this study indicates the analgesic effect of AE which is more significant in chronic phase and this effect may be due to anti-inflammatory ingredients in AE which needs to be more investigated.http://jmp.ir/article-1-181-en.htmlartemisia sieberi besserpainmicemorphineformalin test |
| spellingShingle | A Morshedi MH Dashti - R M Dehghan - H MA Bagherinasab AS Salami The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in Mice Journal of Medicinal Plants artemisia sieberi besser pain mice morphine formalin test |
| title | The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in Mice |
| title_full | The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in Mice |
| title_fullStr | The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in Mice |
| title_full_unstemmed | The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in Mice |
| title_short | The Effect of Artemisia sieberi Besser on Infkammatory and Neurogenic Pain in Mice |
| title_sort | effect of artemisia sieberi besser on infkammatory and neurogenic pain in mice |
| topic | artemisia sieberi besser pain mice morphine formalin test |
| url | http://jmp.ir/article-1-181-en.html |
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