Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-pe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/7/453 |
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| author | Alessandro Mantovani Andrea Dalbeni Denise Peserico Filippo Cattazzo Michele Bevilacqua Gian Luca Salvagno Giuseppe Lippi Giovanni Targher Elisa Danese Cristiano Fava |
| author_facet | Alessandro Mantovani Andrea Dalbeni Denise Peserico Filippo Cattazzo Michele Bevilacqua Gian Luca Salvagno Giuseppe Lippi Giovanni Targher Elisa Danese Cristiano Fava |
| author_sort | Alessandro Mantovani |
| collection | DOAJ |
| description | A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) technique. Multivariable linear regression analyses were undertaken to assess associations between measured plasma BA species and T2DM status after adjustment for confounding factors. The presence of T2DM was significantly associated with higher plasma concentrations of both primary BAs (adjusted-standardized β coefficient: 0.279, <i>p</i> = 0.005) and secondary BAs (standardized β coefficient: 0.508, <i>p</i> < 0.001) after adjustment for age, sex, adiposity measures, serum alanine aminotransferase and use of statins or metformin. More specifically, the presence of T2DM was significantly associated with higher levels of plasma taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, hyodeoxycholic acid, glycodeoxycholic acid, glycolithocholic acid, deoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid and glycodeoxycholic acid (adjusted-standardized β coefficients ranging from 0.315 to 0.600; <i>p</i> < 0.01 or less), as well as with lower plasma levels of cholic acid (adjusted-standardized β coefficient: −0.250, <i>p</i> = 0.013) and taurocholic acid (adjusted-standardized β coefficient: −0.309, <i>p</i> = 0.001). This study shows that there are marked differences in plasma BA profiles between patients with and without T2DM. Further research will be needed to better understand how these differences in plasma BA profiles may interplay with the pathophysiology of T2DM. |
| first_indexed | 2024-03-10T09:32:39Z |
| format | Article |
| id | doaj.art-aeb2c18e1ed34284a242e5a57850bd39 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T09:32:39Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-aeb2c18e1ed34284a242e5a57850bd392023-11-22T04:22:59ZengMDPI AGMetabolites2218-19892021-07-0111745310.3390/metabo11070453Plasma Bile Acid Profile in Patients with and without Type 2 DiabetesAlessandro Mantovani0Andrea Dalbeni1Denise Peserico2Filippo Cattazzo3Michele Bevilacqua4Gian Luca Salvagno5Giuseppe Lippi6Giovanni Targher7Elisa Danese8Cristiano Fava9Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, ItalySection of General Medicine C and Liver Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, ItalySection of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, 37126 Verona, ItalySection of General Medicine C and Liver Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, ItalySection of General Medicine C and Liver Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, ItalySection of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, 37126 Verona, ItalySection of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, 37126 Verona, ItalySection of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, ItalySection of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, 37126 Verona, ItalySection of General Medicine C and Liver Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, ItalyA paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) technique. Multivariable linear regression analyses were undertaken to assess associations between measured plasma BA species and T2DM status after adjustment for confounding factors. The presence of T2DM was significantly associated with higher plasma concentrations of both primary BAs (adjusted-standardized β coefficient: 0.279, <i>p</i> = 0.005) and secondary BAs (standardized β coefficient: 0.508, <i>p</i> < 0.001) after adjustment for age, sex, adiposity measures, serum alanine aminotransferase and use of statins or metformin. More specifically, the presence of T2DM was significantly associated with higher levels of plasma taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, hyodeoxycholic acid, glycodeoxycholic acid, glycolithocholic acid, deoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid and glycodeoxycholic acid (adjusted-standardized β coefficients ranging from 0.315 to 0.600; <i>p</i> < 0.01 or less), as well as with lower plasma levels of cholic acid (adjusted-standardized β coefficient: −0.250, <i>p</i> = 0.013) and taurocholic acid (adjusted-standardized β coefficient: −0.309, <i>p</i> = 0.001). This study shows that there are marked differences in plasma BA profiles between patients with and without T2DM. Further research will be needed to better understand how these differences in plasma BA profiles may interplay with the pathophysiology of T2DM.https://www.mdpi.com/2218-1989/11/7/453type 2 diabetesT2DMbile acidsBAmetabolic syndrome |
| spellingShingle | Alessandro Mantovani Andrea Dalbeni Denise Peserico Filippo Cattazzo Michele Bevilacqua Gian Luca Salvagno Giuseppe Lippi Giovanni Targher Elisa Danese Cristiano Fava Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes Metabolites type 2 diabetes T2DM bile acids BA metabolic syndrome |
| title | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
| title_full | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
| title_fullStr | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
| title_full_unstemmed | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
| title_short | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
| title_sort | plasma bile acid profile in patients with and without type 2 diabetes |
| topic | type 2 diabetes T2DM bile acids BA metabolic syndrome |
| url | https://www.mdpi.com/2218-1989/11/7/453 |
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