Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
Abstract Iron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats an...
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-79971-y |
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| author | Qi Zhang Xiao-Min Lu Min Zhang Chen-Ying Yang Si-Yuan Lv Shi-Fen Li Cai-Yun Zhong Shan-Shan Geng |
| author_facet | Qi Zhang Xiao-Min Lu Min Zhang Chen-Ying Yang Si-Yuan Lv Shi-Fen Li Cai-Yun Zhong Shan-Shan Geng |
| author_sort | Qi Zhang |
| collection | DOAJ |
| description | Abstract Iron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats and their offspring. The IDA female rat model was established with low iron diet and the rats were then mated. After pregnancy, rats were fed diets containing different iron supplements (iron polysaccharide complex, iron protein succinylate and ferrous sulfate) until their offspring were 42 days old. Pregnancy outcomes, haematological, iron metabolism, physical and neurological development indexes were determined. The results showed that all three iron supplements improved the levels of hematological parameters of both mother and offspring rats. After iron supplementation, serum iron, transferrin saturation and serum ferritin levels were increased compared with the IDA group. The level of ferritin light chain in the liver and spleen of both mother and offspring rats in iron supplemented groups was significantly higher than that of the IDA group. The average number of born alive per litter in the iron treatment groups was significantly higher than that in the IDA group. Iron supplements also improved the physical growth and neurobehavioral development of offspring rats. It was also found that iron supplementation improved the expression of ferritin light chain and the synaptic growth associated proteins in the brain and hippocampus. No significant difference was found in the efficacy of three iron supplements. These results suggest that pregnant and postpartum IDA affects pregnancy outcomes, offspring physical development and causes neural impairment. Sufficient iron supplementation can significantly improve IDA and its adverse effects on both mother and offspring. |
| first_indexed | 2024-12-18T05:19:27Z |
| format | Article |
| id | doaj.art-aeb2ccc768bd4d978629572c23db89e1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T05:19:27Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-aeb2ccc768bd4d978629572c23db89e12022-12-21T21:19:42ZengNature PortfolioScientific Reports2045-23222021-01-0111111110.1038/s41598-020-79971-yAdverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplementsQi Zhang0Xiao-Min Lu1Min Zhang2Chen-Ying Yang3Si-Yuan Lv4Shi-Fen Li5Cai-Yun Zhong6Shan-Shan Geng7Department of Nutrition and Food Safety, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Nutrition and Food Safety, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Nutrition and Food Safety, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Nutrition and Food Safety, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Nutrition and Food Safety, Center for Global Health, School of Public Health, Nanjing Medical UniversitySafety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of Jiangsu Province, Nanjing Medical UniversityDepartment of Nutrition and Food Safety, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Nutrition and Food Safety, Center for Global Health, School of Public Health, Nanjing Medical UniversityAbstract Iron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats and their offspring. The IDA female rat model was established with low iron diet and the rats were then mated. After pregnancy, rats were fed diets containing different iron supplements (iron polysaccharide complex, iron protein succinylate and ferrous sulfate) until their offspring were 42 days old. Pregnancy outcomes, haematological, iron metabolism, physical and neurological development indexes were determined. The results showed that all three iron supplements improved the levels of hematological parameters of both mother and offspring rats. After iron supplementation, serum iron, transferrin saturation and serum ferritin levels were increased compared with the IDA group. The level of ferritin light chain in the liver and spleen of both mother and offspring rats in iron supplemented groups was significantly higher than that of the IDA group. The average number of born alive per litter in the iron treatment groups was significantly higher than that in the IDA group. Iron supplements also improved the physical growth and neurobehavioral development of offspring rats. It was also found that iron supplementation improved the expression of ferritin light chain and the synaptic growth associated proteins in the brain and hippocampus. No significant difference was found in the efficacy of three iron supplements. These results suggest that pregnant and postpartum IDA affects pregnancy outcomes, offspring physical development and causes neural impairment. Sufficient iron supplementation can significantly improve IDA and its adverse effects on both mother and offspring.https://doi.org/10.1038/s41598-020-79971-y |
| spellingShingle | Qi Zhang Xiao-Min Lu Min Zhang Chen-Ying Yang Si-Yuan Lv Shi-Fen Li Cai-Yun Zhong Shan-Shan Geng Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements Scientific Reports |
| title | Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements |
| title_full | Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements |
| title_fullStr | Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements |
| title_full_unstemmed | Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements |
| title_short | Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements |
| title_sort | adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements |
| url | https://doi.org/10.1038/s41598-020-79971-y |
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