Human cancer long non-coding RNA transcriptomes.
Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a w...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3185064?pdf=render |
| _version_ | 1818585498788036608 |
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| author | Ewan A Gibb Emily A Vucic Katey S S Enfield Greg L Stewart Kim M Lonergan Jennifer Y Kennett Daiana D Becker-Santos Calum E MacAulay Stephen Lam Carolyn J Brown Wan L Lam |
| author_facet | Ewan A Gibb Emily A Vucic Katey S S Enfield Greg L Stewart Kim M Lonergan Jennifer Y Kennett Daiana D Becker-Santos Calum E MacAulay Stephen Lam Carolyn J Brown Wan L Lam |
| author_sort | Ewan A Gibb |
| collection | DOAJ |
| description | Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a wide range of structural and functional roles in cellular biology. However, the magnitude of the contribution of lncRNA expression to normal human tissues and cancers has not been investigated in a comprehensive manner. In this study, we compiled 272 human serial analysis of gene expression (SAGE) libraries to delineate lncRNA transcription patterns across a broad spectrum of normal human tissues and cancers. Using a novel lncRNA discovery pipeline we parsed over 24 million SAGE tags and report lncRNA expression profiles across a panel of 26 different normal human tissues and 19 human cancers. Our findings show extensive, tissue-specific lncRNA expression in normal tissues and highly aberrant lncRNA expression in human cancers. Here, we present a first generation atlas for lncRNA profiling in cancer. |
| first_indexed | 2024-12-16T08:38:02Z |
| format | Article |
| id | doaj.art-aeb472dd96684630b33b8316a82af454 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:38:02Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-aeb472dd96684630b33b8316a82af4542022-12-21T22:37:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01610e2591510.1371/journal.pone.0025915Human cancer long non-coding RNA transcriptomes.Ewan A GibbEmily A VucicKatey S S EnfieldGreg L StewartKim M LonerganJennifer Y KennettDaiana D Becker-SantosCalum E MacAulayStephen LamCarolyn J BrownWan L LamOnce thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a wide range of structural and functional roles in cellular biology. However, the magnitude of the contribution of lncRNA expression to normal human tissues and cancers has not been investigated in a comprehensive manner. In this study, we compiled 272 human serial analysis of gene expression (SAGE) libraries to delineate lncRNA transcription patterns across a broad spectrum of normal human tissues and cancers. Using a novel lncRNA discovery pipeline we parsed over 24 million SAGE tags and report lncRNA expression profiles across a panel of 26 different normal human tissues and 19 human cancers. Our findings show extensive, tissue-specific lncRNA expression in normal tissues and highly aberrant lncRNA expression in human cancers. Here, we present a first generation atlas for lncRNA profiling in cancer.http://europepmc.org/articles/PMC3185064?pdf=render |
| spellingShingle | Ewan A Gibb Emily A Vucic Katey S S Enfield Greg L Stewart Kim M Lonergan Jennifer Y Kennett Daiana D Becker-Santos Calum E MacAulay Stephen Lam Carolyn J Brown Wan L Lam Human cancer long non-coding RNA transcriptomes. PLoS ONE |
| title | Human cancer long non-coding RNA transcriptomes. |
| title_full | Human cancer long non-coding RNA transcriptomes. |
| title_fullStr | Human cancer long non-coding RNA transcriptomes. |
| title_full_unstemmed | Human cancer long non-coding RNA transcriptomes. |
| title_short | Human cancer long non-coding RNA transcriptomes. |
| title_sort | human cancer long non coding rna transcriptomes |
| url | http://europepmc.org/articles/PMC3185064?pdf=render |
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