Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control study
Abstract Abnormal uterine bleeding (AUB) during the menopausal transition results in reproductive endocrine disorders and both physiological and pathological changes, substantially impacting women’s health. This study aimed to investigate the factors influencing AUB in perimenopausal women. Between...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
|
| Series: | Journal of Health, Population and Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41043-024-00540-4 |
| _version_ | 1827277114669268992 |
|---|---|
| author | Yuan Tian Bin Bai Li Wang Zongchang Zhou Jiahui Tang |
| author_facet | Yuan Tian Bin Bai Li Wang Zongchang Zhou Jiahui Tang |
| author_sort | Yuan Tian |
| collection | DOAJ |
| description | Abstract Abnormal uterine bleeding (AUB) during the menopausal transition results in reproductive endocrine disorders and both physiological and pathological changes, substantially impacting women’s health. This study aimed to investigate the factors influencing AUB in perimenopausal women. Between April 2021 and June 2022, 120 perimenopausal women with AUB in the menopausal transition, diagnosed and treated at the Gynaecology Department of Kunming Tongren Hospital, were included in the case group. Concurrently, women undergoing routine health examinations at the same hospital were randomly selected as the control group. Univariate and multivariate logistic regression analyses identified factors related to AUB. The univariate analysis revealed significant associations (P < 0.05) between AUB and several factors, including age, body mass index (BMI), age at menarche, gravidity, and intrauterine device (IUD) placement in perimenopausal women. The multivariate regression analysis indicated that the independent risk factors for AUB include benign endometrial lesions (odds ratio [OR] 5.243, 95% confidence interval [CI] 3.082–9.458, P < 0.001), endometrial thickness ≥ 10 mm (OR 1.573, 95% CI 0.984–3.287, P < 0.001), age ≥ 50 years (OR 2.045, 95% CI 1.035–4.762, P = 0.001), BMI ≥ 25 kg/m2 (OR 2.436, 95% CI 1.43–4.86, P = 0.002), and IUD placement (OR 2.458, 95% CI 1.253–4.406, P < 0.001). Abnormal uterine bleeding during the menopausal transition is associated with several factors, including age, BMI, and IUD placement, highlighting the importance of early screening for these risk factors in the diagnosis and treatment of AUB. |
| first_indexed | 2024-04-24T07:14:23Z |
| format | Article |
| id | doaj.art-aeb483555bcb402bbe9c8d9a87bcaffa |
| institution | Directory Open Access Journal |
| issn | 2072-1315 |
| language | English |
| last_indexed | 2024-04-24T07:14:23Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj.art-aeb483555bcb402bbe9c8d9a87bcaffa2024-04-21T11:22:28ZengBMCJournal of Health, Population and Nutrition2072-13152024-04-014311910.1186/s41043-024-00540-4Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control studyYuan Tian0Bin Bai1Li Wang2Zongchang Zhou3Jiahui Tang4Department of Obstetrics and Gynecology, Clinical Skill Experiment Center of Haiyuan College, Kunming Medical UniversityDepartment of Critical Medicine, The Third People’s Hospital of KunmingDepartment of Gynaecology, Kunming Tongren HospitalDepartment of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Shuifu People’s HospitalDepartment of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Shuifu People’s HospitalAbstract Abnormal uterine bleeding (AUB) during the menopausal transition results in reproductive endocrine disorders and both physiological and pathological changes, substantially impacting women’s health. This study aimed to investigate the factors influencing AUB in perimenopausal women. Between April 2021 and June 2022, 120 perimenopausal women with AUB in the menopausal transition, diagnosed and treated at the Gynaecology Department of Kunming Tongren Hospital, were included in the case group. Concurrently, women undergoing routine health examinations at the same hospital were randomly selected as the control group. Univariate and multivariate logistic regression analyses identified factors related to AUB. The univariate analysis revealed significant associations (P < 0.05) between AUB and several factors, including age, body mass index (BMI), age at menarche, gravidity, and intrauterine device (IUD) placement in perimenopausal women. The multivariate regression analysis indicated that the independent risk factors for AUB include benign endometrial lesions (odds ratio [OR] 5.243, 95% confidence interval [CI] 3.082–9.458, P < 0.001), endometrial thickness ≥ 10 mm (OR 1.573, 95% CI 0.984–3.287, P < 0.001), age ≥ 50 years (OR 2.045, 95% CI 1.035–4.762, P = 0.001), BMI ≥ 25 kg/m2 (OR 2.436, 95% CI 1.43–4.86, P = 0.002), and IUD placement (OR 2.458, 95% CI 1.253–4.406, P < 0.001). Abnormal uterine bleeding during the menopausal transition is associated with several factors, including age, BMI, and IUD placement, highlighting the importance of early screening for these risk factors in the diagnosis and treatment of AUB.https://doi.org/10.1186/s41043-024-00540-4Abnormal uterine bleedingDiagnosisInfluencing factorsPerimenopauseTreatment |
| spellingShingle | Yuan Tian Bin Bai Li Wang Zongchang Zhou Jiahui Tang Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control study Journal of Health, Population and Nutrition Abnormal uterine bleeding Diagnosis Influencing factors Perimenopause Treatment |
| title | Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control study |
| title_full | Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control study |
| title_fullStr | Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control study |
| title_full_unstemmed | Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control study |
| title_short | Contributing factors related to abnormal uterine bleeding in perimenopausal women: a case–control study |
| title_sort | contributing factors related to abnormal uterine bleeding in perimenopausal women a case control study |
| topic | Abnormal uterine bleeding Diagnosis Influencing factors Perimenopause Treatment |
| url | https://doi.org/10.1186/s41043-024-00540-4 |
| work_keys_str_mv | AT yuantian contributingfactorsrelatedtoabnormaluterinebleedinginperimenopausalwomenacasecontrolstudy AT binbai contributingfactorsrelatedtoabnormaluterinebleedinginperimenopausalwomenacasecontrolstudy AT liwang contributingfactorsrelatedtoabnormaluterinebleedinginperimenopausalwomenacasecontrolstudy AT zongchangzhou contributingfactorsrelatedtoabnormaluterinebleedinginperimenopausalwomenacasecontrolstudy AT jiahuitang contributingfactorsrelatedtoabnormaluterinebleedinginperimenopausalwomenacasecontrolstudy |