A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary study
Chao An,* Xin Li,* Ping Liang, Jie Yu, Zhigang Cheng, Zhiyu Han, Fangyi Liu, Linan Dong Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, 100853, China *These authors contributed equally to this work Purpose: This study aimed to investigate the clinical value of a tumo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-02-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-tumor-map-generated-from-three-dimensional-visualization-of-image-fu-peer-reviewed-article-CMAR |
| _version_ | 1818988480689078272 |
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| author | An C Li X Liang P Yu J Cheng Z Han Z Liu F Dong L |
| author_facet | An C Li X Liang P Yu J Cheng Z Han Z Liu F Dong L |
| author_sort | An C |
| collection | DOAJ |
| description | Chao An,* Xin Li,* Ping Liang, Jie Yu, Zhigang Cheng, Zhiyu Han, Fangyi Liu, Linan Dong Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, 100853, China *These authors contributed equally to this work Purpose: This study aimed to investigate the clinical value of a tumor map for assessing the ablative effect after ultrasound-guided percutaneous microwave ablation (US-PMWA) for hepatocellular carcinoma (HCC). Methods: The medical records of 68 patients (49 male and 19 female, 59.9±12.7 years) with HCC who underwent US-PMWA from May 2013 to May 2017 were reviewed. A tumor map was generated from the fusion of three-dimensional (3D) visualization images based on the preoperative target tumor and postoperative ablation area, to evaluate whether the ablation area covering the tumor has reached a 5 mm ablative margin (AM). The lesions were divided into two groups according to the tumor maps: group A (failed to achieve AM) and group B (achieved AM). The cumulative local tumor progression (LTP) rates of both groups were statistically analyzed using the log-rank test. Results: Success rate of tumor map generation was 100% (68/68), and no residual tumors were found. MWA-related 3D images, which included target tumor volume, ablation area volume, and residual liver ratio, were compared between groups A and B (P=0.295, P=0.772, and P=0.527, respectively). Technique effectiveness rate (91.7% vs 100%) was achieved in the two groups, showing no significant statistical differences (P=0.672). The 3-, 6-, 9-, and 12-month LTP rate was 8.3%, 16.7%, 20.8%, and 34%, respectively, for group A and 0%, 2.8%, 2.8%, and 2.8%, respectively, for group B, showing significant statistical differences (P<0.001) between the two groups. Conclusion: The novel technology of tumor map generated from 3D visualization of image fusion is feasible and useful in evaluating the ablative effect of US-PMWA for HCC. Keywords: three-dimensional visualization, tumor map, image fusion, microwave ablation, hepatocellular carcinoma |
| first_indexed | 2024-12-20T19:23:15Z |
| format | Article |
| id | doaj.art-aeb8f16ab20c40f8905e89303a751c09 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-20T19:23:15Z |
| publishDate | 2019-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-aeb8f16ab20c40f8905e89303a751c092022-12-21T19:28:57ZengDove Medical PressCancer Management and Research1179-13222019-02-01Volume 111569157844131A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary studyAn CLi XLiang PYu JCheng ZHan ZLiu FDong LChao An,* Xin Li,* Ping Liang, Jie Yu, Zhigang Cheng, Zhiyu Han, Fangyi Liu, Linan Dong Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, 100853, China *These authors contributed equally to this work Purpose: This study aimed to investigate the clinical value of a tumor map for assessing the ablative effect after ultrasound-guided percutaneous microwave ablation (US-PMWA) for hepatocellular carcinoma (HCC). Methods: The medical records of 68 patients (49 male and 19 female, 59.9±12.7 years) with HCC who underwent US-PMWA from May 2013 to May 2017 were reviewed. A tumor map was generated from the fusion of three-dimensional (3D) visualization images based on the preoperative target tumor and postoperative ablation area, to evaluate whether the ablation area covering the tumor has reached a 5 mm ablative margin (AM). The lesions were divided into two groups according to the tumor maps: group A (failed to achieve AM) and group B (achieved AM). The cumulative local tumor progression (LTP) rates of both groups were statistically analyzed using the log-rank test. Results: Success rate of tumor map generation was 100% (68/68), and no residual tumors were found. MWA-related 3D images, which included target tumor volume, ablation area volume, and residual liver ratio, were compared between groups A and B (P=0.295, P=0.772, and P=0.527, respectively). Technique effectiveness rate (91.7% vs 100%) was achieved in the two groups, showing no significant statistical differences (P=0.672). The 3-, 6-, 9-, and 12-month LTP rate was 8.3%, 16.7%, 20.8%, and 34%, respectively, for group A and 0%, 2.8%, 2.8%, and 2.8%, respectively, for group B, showing significant statistical differences (P<0.001) between the two groups. Conclusion: The novel technology of tumor map generated from 3D visualization of image fusion is feasible and useful in evaluating the ablative effect of US-PMWA for HCC. Keywords: three-dimensional visualization, tumor map, image fusion, microwave ablation, hepatocellular carcinomahttps://www.dovepress.com/a-tumor-map-generated-from-three-dimensional-visualization-of-image-fu-peer-reviewed-article-CMARThree-dimensional visualisationtumour mapimage fusionmicrowave ablationhepatocellular carcinoma |
| spellingShingle | An C Li X Liang P Yu J Cheng Z Han Z Liu F Dong L A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary study Cancer Management and Research Three-dimensional visualisation tumour map image fusion microwave ablation hepatocellular carcinoma |
| title | A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary study |
| title_full | A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary study |
| title_fullStr | A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary study |
| title_full_unstemmed | A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary study |
| title_short | A tumor map generated from three-dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma: a preliminary study |
| title_sort | tumor map generated from three dimensional visualization of image fusion for the assessment of microwave ablation of hepatocellular carcinoma a preliminary study |
| topic | Three-dimensional visualisation tumour map image fusion microwave ablation hepatocellular carcinoma |
| url | https://www.dovepress.com/a-tumor-map-generated-from-three-dimensional-visualization-of-image-fu-peer-reviewed-article-CMAR |
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