Combination of umbilical cord mesenchymal stem cells and standard immunosuppressive regimen for pediatric patients with severe aplastic anemia

Combination of umbilical cord mesenchymal stem cells and standard immunosuppressive regimen for pediatric patients with severe aplastic anemia

Abstract Background Defects of bone marrow mesenchymal stem cells (BM-MSCs) in proliferation and differentiation are involved in the pathophysiology of aplastic anemia (AA). Infusion of umbilical cord mesenchymal stem cells (UC-MSCs) may improve the efficacy of immunosuppressive therapy (IST) in chi...

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Bibliographic Details
Main Authors: Yang Lan, Fang Liu, Lixian Chang, Lipeng Liu, Yingchi Zhang, Meihui Yi, Yuli Cai, Jing Feng, Zhibo Han, Zhongchao Han, Xiaofan Zhu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Pediatrics
Subjects:
Child
Immunosuppressive therapy
Mesenchymal stem cell
Severe aplastic anemia
Umbilical cord
Online Access:https://doi.org/10.1186/s12887-021-02562-x

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