Bacterial extracellular vesicles – brain invaders? A systematic review
IntroductionKnowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, changes in the gut microbiota composition have been reported as a part of the pathology in numerous neurodegenerative diseases. Bacterial extracellular vesicles (EVs) have been sugge...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1227655/full |
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| author | Anna Kaisanlahti Anna Kaisanlahti Sonja Salmi Sohvi Kumpula Sohvi Kumpula Sajeen Bahadur Amatya Sajeen Bahadur Amatya Jenni Turunen Jenni Turunen Mysore Tejesvi Mysore Tejesvi Nadiya Byts Nadiya Byts Terhi Tapiainen Terhi Tapiainen Terhi Tapiainen Justus Reunanen Justus Reunanen |
| author_facet | Anna Kaisanlahti Anna Kaisanlahti Sonja Salmi Sohvi Kumpula Sohvi Kumpula Sajeen Bahadur Amatya Sajeen Bahadur Amatya Jenni Turunen Jenni Turunen Mysore Tejesvi Mysore Tejesvi Nadiya Byts Nadiya Byts Terhi Tapiainen Terhi Tapiainen Terhi Tapiainen Justus Reunanen Justus Reunanen |
| author_sort | Anna Kaisanlahti |
| collection | DOAJ |
| description | IntroductionKnowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, changes in the gut microbiota composition have been reported as a part of the pathology in numerous neurodegenerative diseases. Bacterial extracellular vesicles (EVs) have been suggested as a novel mechanism for the crosstalk between the brain and gut microbiota, physiologically connecting the observed changes in the brain to gut microbiota dysbiosis.MethodsPublications reporting findings on bacterial EVs passage through the blood–brain barrier were identified in PubMed and Scopus databases.ResultsThe literature search yielded 138 non-duplicate publications, from which 113 records were excluded in title and abstract screening step. From 25 publications subjected to full-text screening, 8 were excluded. The resulting 17 publications were considered for the review.DiscussionBacterial EVs have been described with capability to cross the blood–brain barrier, but the mechanisms behind the crossing remain largely unknown. Importantly, very little data exists in this context on EVs secreted by the human gut microbiota. This systematic review summarizes the present evidence of bacterial EVs crossing the blood–brain barrier and highlights the importance of future research on gut microbiota-derived EVs in the context of gut-brain communication across the blood–brain barrier. |
| first_indexed | 2024-03-12T00:54:31Z |
| format | Article |
| id | doaj.art-aebbeb7ec87e4027b8e27dccd933ce8e |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-12T00:54:31Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-aebbeb7ec87e4027b8e27dccd933ce8e2023-09-14T14:28:25ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-09-011610.3389/fnmol.2023.12276551227655Bacterial extracellular vesicles – brain invaders? A systematic reviewAnna Kaisanlahti0Anna Kaisanlahti1Sonja Salmi2Sohvi Kumpula3Sohvi Kumpula4Sajeen Bahadur Amatya5Sajeen Bahadur Amatya6Jenni Turunen7Jenni Turunen8Mysore Tejesvi9Mysore Tejesvi10Nadiya Byts11Nadiya Byts12Terhi Tapiainen13Terhi Tapiainen14Terhi Tapiainen15Justus Reunanen16Justus Reunanen17Biocenter Oulu, University of Oulu, Oulu, FinlandResearch Unit of Translational Medicine, University of Oulu, Oulu, FinlandDisease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, FinlandBiocenter Oulu, University of Oulu, Oulu, FinlandResearch Unit of Translational Medicine, University of Oulu, Oulu, FinlandBiocenter Oulu, University of Oulu, Oulu, FinlandResearch Unit of Translational Medicine, University of Oulu, Oulu, FinlandBiocenter Oulu, University of Oulu, Oulu, FinlandResearch Unit of Clinical Medicine, University of Oulu, Oulu, FinlandBiocenter Oulu, University of Oulu, Oulu, FinlandDepartment of Ecology and Genetics, Faculty of Science, University of Oulu, Oulu, FinlandBiocenter Oulu, University of Oulu, Oulu, FinlandResearch Unit of Translational Medicine, University of Oulu, Oulu, FinlandBiocenter Oulu, University of Oulu, Oulu, FinlandResearch Unit of Clinical Medicine, University of Oulu, Oulu, FinlandDepartment of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, FinlandBiocenter Oulu, University of Oulu, Oulu, FinlandResearch Unit of Translational Medicine, University of Oulu, Oulu, FinlandIntroductionKnowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, changes in the gut microbiota composition have been reported as a part of the pathology in numerous neurodegenerative diseases. Bacterial extracellular vesicles (EVs) have been suggested as a novel mechanism for the crosstalk between the brain and gut microbiota, physiologically connecting the observed changes in the brain to gut microbiota dysbiosis.MethodsPublications reporting findings on bacterial EVs passage through the blood–brain barrier were identified in PubMed and Scopus databases.ResultsThe literature search yielded 138 non-duplicate publications, from which 113 records were excluded in title and abstract screening step. From 25 publications subjected to full-text screening, 8 were excluded. The resulting 17 publications were considered for the review.DiscussionBacterial EVs have been described with capability to cross the blood–brain barrier, but the mechanisms behind the crossing remain largely unknown. Importantly, very little data exists in this context on EVs secreted by the human gut microbiota. This systematic review summarizes the present evidence of bacterial EVs crossing the blood–brain barrier and highlights the importance of future research on gut microbiota-derived EVs in the context of gut-brain communication across the blood–brain barrier.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1227655/fullmicrobiotabacteriaextracellular vesiclesbrainblood–brain barrier |
| spellingShingle | Anna Kaisanlahti Anna Kaisanlahti Sonja Salmi Sohvi Kumpula Sohvi Kumpula Sajeen Bahadur Amatya Sajeen Bahadur Amatya Jenni Turunen Jenni Turunen Mysore Tejesvi Mysore Tejesvi Nadiya Byts Nadiya Byts Terhi Tapiainen Terhi Tapiainen Terhi Tapiainen Justus Reunanen Justus Reunanen Bacterial extracellular vesicles – brain invaders? A systematic review Frontiers in Molecular Neuroscience microbiota bacteria extracellular vesicles brain blood–brain barrier |
| title | Bacterial extracellular vesicles – brain invaders? A systematic review |
| title_full | Bacterial extracellular vesicles – brain invaders? A systematic review |
| title_fullStr | Bacterial extracellular vesicles – brain invaders? A systematic review |
| title_full_unstemmed | Bacterial extracellular vesicles – brain invaders? A systematic review |
| title_short | Bacterial extracellular vesicles – brain invaders? A systematic review |
| title_sort | bacterial extracellular vesicles brain invaders a systematic review |
| topic | microbiota bacteria extracellular vesicles brain blood–brain barrier |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1227655/full |
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