Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
Cervical lymph nodes biopsies from 31 HIV positive patients (with or without AIDS) were studied by histologic methods and immunohistochemistry (StreptABC staining of paraffin sections) to identify cellular and extracellular matrix components. The results were the following: (1) the biopsies were inc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1996-06-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000300023 |
| _version_ | 1797757414748979200 |
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| author | DD Paiva JC Morais J Pilotto V Veloso F Duarte HL Lenzi |
| author_facet | DD Paiva JC Morais J Pilotto V Veloso F Duarte HL Lenzi |
| author_sort | DD Paiva |
| collection | DOAJ |
| description | Cervical lymph nodes biopsies from 31 HIV positive patients (with or without AIDS) were studied by histologic methods and immunohistochemistry (StreptABC staining of paraffin sections) to identify cellular and extracellular matrix components. The results were the following: (1) the biopsies were included in the stages of follicular hyperplasia without fragmentation FH-FF (4 cases); follicular hyperplasia with follicular fragmentation FH+FF (16 cases); follicular involution FI (6 cases) and diffuse pattern DP (5 cases); (2) the most important alteration was the germinal centers disruption due to follicle lysis, which began in the light zone; (3) there was coincidence between intrafollicular hemorrhages and segmental hyaline mycroangiopathy; (4) during the progression of the disease occurred: (a) an increase in the number of mast cells, CD68+ and Mac387+ macrophages; (b) a diffuse augment of collagen III, elastic fibers, laminin, fibronectin and proteoglycans; (c) maintenance of Factor VIII - related antigens in the vascular endothelial cells, with decrease in the expression of Ulex-Europeus I lectin. Follicular hyperplasia (FH-FF or FH+FF) was the most common histologic pattern recognized in the lymph nodes of patients without AIDS and follicular involution and difuse pattern were seen in those who had AIDS. The results indicate that the lymph node biopsies may provide important information about the evolutive stage of the disease and its prognosis. |
| first_indexed | 2024-03-12T18:15:30Z |
| format | Article |
| id | doaj.art-aebffb9569444f8396cc59d16f4a9c30 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:15:30Z |
| publishDate | 1996-06-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-aebffb9569444f8396cc59d16f4a9c302023-08-02T09:10:44ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601996-06-0191337137910.1590/S0074-02761996000300023Spectrum of Morphologic Changes of Lymph Nodes in HIV InfectionDD PaivaJC MoraisJ PilottoV VelosoF DuarteHL LenziCervical lymph nodes biopsies from 31 HIV positive patients (with or without AIDS) were studied by histologic methods and immunohistochemistry (StreptABC staining of paraffin sections) to identify cellular and extracellular matrix components. The results were the following: (1) the biopsies were included in the stages of follicular hyperplasia without fragmentation FH-FF (4 cases); follicular hyperplasia with follicular fragmentation FH+FF (16 cases); follicular involution FI (6 cases) and diffuse pattern DP (5 cases); (2) the most important alteration was the germinal centers disruption due to follicle lysis, which began in the light zone; (3) there was coincidence between intrafollicular hemorrhages and segmental hyaline mycroangiopathy; (4) during the progression of the disease occurred: (a) an increase in the number of mast cells, CD68+ and Mac387+ macrophages; (b) a diffuse augment of collagen III, elastic fibers, laminin, fibronectin and proteoglycans; (c) maintenance of Factor VIII - related antigens in the vascular endothelial cells, with decrease in the expression of Ulex-Europeus I lectin. Follicular hyperplasia (FH-FF or FH+FF) was the most common histologic pattern recognized in the lymph nodes of patients without AIDS and follicular involution and difuse pattern were seen in those who had AIDS. The results indicate that the lymph node biopsies may provide important information about the evolutive stage of the disease and its prognosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000300023lymph nodeHIVAIDSextracellular matrixmast cellsmycroangiopathy |
| spellingShingle | DD Paiva JC Morais J Pilotto V Veloso F Duarte HL Lenzi Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection Memorias do Instituto Oswaldo Cruz lymph node HIV AIDS extracellular matrix mast cells mycroangiopathy |
| title | Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection |
| title_full | Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection |
| title_fullStr | Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection |
| title_full_unstemmed | Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection |
| title_short | Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection |
| title_sort | spectrum of morphologic changes of lymph nodes in hiv infection |
| topic | lymph node HIV AIDS extracellular matrix mast cells mycroangiopathy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000300023 |
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