Agitation-dependent biomechanical forces modulate GPVI receptor expression and platelet adhesion capacity during storage
Abstract Background Continuous agitation during storage slows down the platelet storage lesions. However, in special circumstances, manual-mixing can be alternatively used to store products for short time periods without compromising platelet quality. Based on this finding, and given the role of she...
Main Authors: | Ehteramolsadat Hosseini, Amin Solouki, Masood Haghshenas, Mehran Ghasemzadeh, Simone M. Schoenwaelder |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2022-01-01
|
Series: | Thrombosis Journal |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12959-021-00359-7 |
Similar Items
-
GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion
by: Ehteramolsadat Hosseini, et al.
Published: (2017-07-01) -
Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation
by: Raluca A. I. Neagoe, et al.
Published: (2022-03-01) -
Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets
by: Chiara Pallini, et al.
Published: (2021-01-01) -
The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors
by: Chek Ziu Koo, et al.
Published: (2022-02-01) -
Comparison of the GPVI inhibitors losartan and honokiol
by: Marie-Blanche Onselaer, et al.
Published: (2020-02-01)