Ceftriaxone-induced Agranulocytosis
Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a b...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2021-01-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/2215 |
| _version_ | 1818610826488053760 |
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| author | Lénio Couto André Goulart Ivone Valadão Magda Garça Maria Beatriz Santos Pedro Cota Carolina Teixeira |
| author_facet | Lénio Couto André Goulart Ivone Valadão Magda Garça Maria Beatriz Santos Pedro Cota Carolina Teixeira |
| author_sort | Lénio Couto |
| collection | DOAJ |
| description | Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a brain abscess was diagnosed and ceftriaxone was commenced. Neutropenic fever occurred on the 29th day of therapy with a cumulative dose of 116 g ceftriaxone and a neutrophil nadir of 0.1×109/l. Ceftriaxone was withheld, filgrastim was administered for 3 days and neutrophil normalization was achieved. Although rare, ceftriaxone-induced agranulocytosis may occur in patients on a long course of ceftriaxone therapy. Prompt recognition and drug withdrawal are required. |
| first_indexed | 2024-12-16T15:20:36Z |
| format | Article |
| id | doaj.art-aec62f7ff1fc4de8b762559d8a9c5c91 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-16T15:20:36Z |
| publishDate | 2021-01-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-aec62f7ff1fc4de8b762559d8a9c5c912022-12-21T22:26:39ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942021-01-0110.12890/2021_0022151831Ceftriaxone-induced AgranulocytosisLénio Couto0André Goulart1Ivone Valadão2Magda Garça3Maria Beatriz Santos4Pedro Cota5Carolina Teixeira6Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, PortugalHospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, PortugalHospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, PortugalHospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, PortugalHospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, PortugalHospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, PortugalHospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, PortugalCeftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a brain abscess was diagnosed and ceftriaxone was commenced. Neutropenic fever occurred on the 29th day of therapy with a cumulative dose of 116 g ceftriaxone and a neutrophil nadir of 0.1×109/l. Ceftriaxone was withheld, filgrastim was administered for 3 days and neutrophil normalization was achieved. Although rare, ceftriaxone-induced agranulocytosis may occur in patients on a long course of ceftriaxone therapy. Prompt recognition and drug withdrawal are required.https://www.ejcrim.com/index.php/EJCRIM/article/view/2215ceftriaxoneneutropeniadrug-induced agranulocytosis |
| spellingShingle | Lénio Couto André Goulart Ivone Valadão Magda Garça Maria Beatriz Santos Pedro Cota Carolina Teixeira Ceftriaxone-induced Agranulocytosis European Journal of Case Reports in Internal Medicine ceftriaxone neutropenia drug-induced agranulocytosis |
| title | Ceftriaxone-induced Agranulocytosis |
| title_full | Ceftriaxone-induced Agranulocytosis |
| title_fullStr | Ceftriaxone-induced Agranulocytosis |
| title_full_unstemmed | Ceftriaxone-induced Agranulocytosis |
| title_short | Ceftriaxone-induced Agranulocytosis |
| title_sort | ceftriaxone induced agranulocytosis |
| topic | ceftriaxone neutropenia drug-induced agranulocytosis |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/2215 |
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