Integrins and ERp57 Coordinate to Regulate Cell Surface Calreticulin in Immunogenic Cell Death

Integrins and ERp57 Coordinate to Regulate Cell Surface Calreticulin in Immunogenic Cell Death

Therapy-induced presentation of cell surface calreticulin (CRT) is a pro-phagocytic immunogen beneficial for invoking anti-tumor immunity. Here, we characterized the roles of ERp57 and α-integrins as CRT-interacting proteins that coordinately regulate CRT translocation from the ER to the surface dur...

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Bibliographic Details
Main Authors: Chi-Chao Liu, Pascal Leclair, Foujan Pedari, Heidi Vieira, Mahdis Monajemi, Laura M. Sly, Gregor S. Reid, Chinten James Lim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
integrins
calreticulin
ERp57
immunogenic cell death
leukemia
cell adhesion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00411/full

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