The characteristics and molecular targets of antiarrhythmic natural products
Arrhythmia is one of the most common cardiovascular diseases. The search for new drugs to suppress various types of cardiac arrhythmias has always been the focus of attention. In the past decade, the screening of antiarrhythmic active substances from plants has received extensive attention. These na...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223015603 |
| _version_ | 1797630627916283904 |
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| author | Jun Yang Kejun Ye Rui Zhang Xinrong Fan Rui Xiong Shiyu Zhang Qiming Liu Miao Lin Bin Wang Xiaoqiu Tan Qiang Wen Xianhong Ou |
| author_facet | Jun Yang Kejun Ye Rui Zhang Xinrong Fan Rui Xiong Shiyu Zhang Qiming Liu Miao Lin Bin Wang Xiaoqiu Tan Qiang Wen Xianhong Ou |
| author_sort | Jun Yang |
| collection | DOAJ |
| description | Arrhythmia is one of the most common cardiovascular diseases. The search for new drugs to suppress various types of cardiac arrhythmias has always been the focus of attention. In the past decade, the screening of antiarrhythmic active substances from plants has received extensive attention. These natural compounds have obvious antiarrhythmic effects, and chemical modifications based on natural compounds have greatly increased their pharmacological properties. The chemical modification of botanical antiarrhythmic drugs is closely related to the development of new and promising drugs. Therefore, the structural characteristics and action targets of natural compounds with antiarrhythmic effects are reviewed in this paper, so that pharmacologists can select antiarrhythmic lead compounds from natural compounds based on the disease target - chemical structural characteristics. |
| first_indexed | 2024-03-11T11:10:51Z |
| format | Article |
| id | doaj.art-aeca184bd06b427398addc812313384f |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:10:51Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-aeca184bd06b427398addc812313384f2023-11-12T04:39:14ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115762The characteristics and molecular targets of antiarrhythmic natural productsJun Yang0Kejun Ye1Rui Zhang2Xinrong Fan3Rui Xiong4Shiyu Zhang5Qiming Liu6Miao Lin7Bin Wang8Xiaoqiu Tan9Qiang Wen10Xianhong Ou11Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; Department of Pharmacy, Santai County People's Hospital of Sichuan Province, Mianyang 621100, ChinaKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; Pharmacy Department, Chongqing Armed Police Corps Hospital, Chongqing 400061, ChinaKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Pharmacy of the 958 Hospital of Chinese PLA/Jiangbei Campus, The First Affiliated Hospital of Army Medical University, Chongqing 400020, ChinaKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, ChinaSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China; Correspondence to: Institute of Cardiovascular Research, Southwest Medical University, 1 Xianglin of Longmatan, Luzhou 646000, Sichuan, China.Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Correspondence to: Institute of Cardiovascular Research, Southwest Medical University, 1 Xianglin of Longmatan, Luzhou 646000, Sichuan, China.Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi Province, China; Correspondence to: Institute of Cardiovascular Research, Southwest Medical University, 1 Xianglin of Longmatan, Luzhou 646000, Sichuan, China.Arrhythmia is one of the most common cardiovascular diseases. The search for new drugs to suppress various types of cardiac arrhythmias has always been the focus of attention. In the past decade, the screening of antiarrhythmic active substances from plants has received extensive attention. These natural compounds have obvious antiarrhythmic effects, and chemical modifications based on natural compounds have greatly increased their pharmacological properties. The chemical modification of botanical antiarrhythmic drugs is closely related to the development of new and promising drugs. Therefore, the structural characteristics and action targets of natural compounds with antiarrhythmic effects are reviewed in this paper, so that pharmacologists can select antiarrhythmic lead compounds from natural compounds based on the disease target - chemical structural characteristics.http://www.sciencedirect.com/science/article/pii/S0753332223015603Natural productAntiarrhythmicCardioprotectionAction characteristicsTargetReview |
| spellingShingle | Jun Yang Kejun Ye Rui Zhang Xinrong Fan Rui Xiong Shiyu Zhang Qiming Liu Miao Lin Bin Wang Xiaoqiu Tan Qiang Wen Xianhong Ou The characteristics and molecular targets of antiarrhythmic natural products Biomedicine & Pharmacotherapy Natural product Antiarrhythmic Cardioprotection Action characteristics Target Review |
| title | The characteristics and molecular targets of antiarrhythmic natural products |
| title_full | The characteristics and molecular targets of antiarrhythmic natural products |
| title_fullStr | The characteristics and molecular targets of antiarrhythmic natural products |
| title_full_unstemmed | The characteristics and molecular targets of antiarrhythmic natural products |
| title_short | The characteristics and molecular targets of antiarrhythmic natural products |
| title_sort | characteristics and molecular targets of antiarrhythmic natural products |
| topic | Natural product Antiarrhythmic Cardioprotection Action characteristics Target Review |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223015603 |
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