Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics
Nanoparticles have demonstrated several advantages for biomedical applications, including for the development of multifunctional agents as innovative medicine. Silica nanoparticles hold a special position among the various types of functional nanoparticles, due to their unique structural and functio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/1/73 |
| _version_ | 1827601434601848832 |
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| author | Chihiro Mochizuki Junna Nakamura Michihiro Nakamura |
| author_facet | Chihiro Mochizuki Junna Nakamura Michihiro Nakamura |
| author_sort | Chihiro Mochizuki |
| collection | DOAJ |
| description | Nanoparticles have demonstrated several advantages for biomedical applications, including for the development of multifunctional agents as innovative medicine. Silica nanoparticles hold a special position among the various types of functional nanoparticles, due to their unique structural and functional properties. The recent development of silica nanoparticles has led to a new trend in light-based nanomedicines. The application of light provides many advantages for in vivo imaging and therapy of certain diseases, including cancer. Mesoporous and non-porous silica nanoparticles have high potential for light-based nanomedicine. Each silica nanoparticle has a unique structure, which incorporates various functions to utilize optical properties. Such advantages enable silica nanoparticles to perform powerful and advanced optical imaging, from the in vivo level to the nano and micro levels, using not only visible light but also near-infrared light. Furthermore, applications such as photodynamic therapy, in which a lesion site is specifically irradiated with light to treat it, have also been advancing. Silica nanoparticles have shown the potential to play important roles in the integration of light-based diagnostics and therapeutics, termed “photo-theranostics”. Here, we review the recent development and progress of non-porous silica nanoparticles toward cancer “photo-theranostics”. |
| first_indexed | 2024-03-09T04:56:27Z |
| format | Article |
| id | doaj.art-aeca4349f2464921a8c54891e536355f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T04:56:27Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-aeca4349f2464921a8c54891e536355f2023-12-03T13:05:53ZengMDPI AGBiomedicines2227-90592021-01-01917310.3390/biomedicines9010073Development of Non-Porous Silica Nanoparticles towards Cancer Photo-TheranosticsChihiro Mochizuki0Junna Nakamura1Michihiro Nakamura2Department of Organ Anatomy & Nanomedicine, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Organ Anatomy & Nanomedicine, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Organ Anatomy & Nanomedicine, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanNanoparticles have demonstrated several advantages for biomedical applications, including for the development of multifunctional agents as innovative medicine. Silica nanoparticles hold a special position among the various types of functional nanoparticles, due to their unique structural and functional properties. The recent development of silica nanoparticles has led to a new trend in light-based nanomedicines. The application of light provides many advantages for in vivo imaging and therapy of certain diseases, including cancer. Mesoporous and non-porous silica nanoparticles have high potential for light-based nanomedicine. Each silica nanoparticle has a unique structure, which incorporates various functions to utilize optical properties. Such advantages enable silica nanoparticles to perform powerful and advanced optical imaging, from the in vivo level to the nano and micro levels, using not only visible light but also near-infrared light. Furthermore, applications such as photodynamic therapy, in which a lesion site is specifically irradiated with light to treat it, have also been advancing. Silica nanoparticles have shown the potential to play important roles in the integration of light-based diagnostics and therapeutics, termed “photo-theranostics”. Here, we review the recent development and progress of non-porous silica nanoparticles toward cancer “photo-theranostics”.https://www.mdpi.com/2227-9059/9/1/73silica nanoparticlesorganically modified silica (ORMOSIL) nanoparticlesorganosilica nanoparticlesimagingtherapytheranostics |
| spellingShingle | Chihiro Mochizuki Junna Nakamura Michihiro Nakamura Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics Biomedicines silica nanoparticles organically modified silica (ORMOSIL) nanoparticles organosilica nanoparticles imaging therapy theranostics |
| title | Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics |
| title_full | Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics |
| title_fullStr | Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics |
| title_full_unstemmed | Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics |
| title_short | Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics |
| title_sort | development of non porous silica nanoparticles towards cancer photo theranostics |
| topic | silica nanoparticles organically modified silica (ORMOSIL) nanoparticles organosilica nanoparticles imaging therapy theranostics |
| url | https://www.mdpi.com/2227-9059/9/1/73 |
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