Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives
Alcohol-related liver disease (ALD) refers to a spectrum of liver manifestations ranging from fatty liver diseases, steatohepatitis, and fibrosis/cirrhosis with chronic inflammation primarily due to excessive alcohol use. Currently, ALD is considered as one of the most prevalent causes of liver dise...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/10/2530 |
| _version_ | 1797475018646487040 |
|---|---|
| author | Yoonji Ha Inju Jeong Tae Hyun Kim |
| author_facet | Yoonji Ha Inju Jeong Tae Hyun Kim |
| author_sort | Yoonji Ha |
| collection | DOAJ |
| description | Alcohol-related liver disease (ALD) refers to a spectrum of liver manifestations ranging from fatty liver diseases, steatohepatitis, and fibrosis/cirrhosis with chronic inflammation primarily due to excessive alcohol use. Currently, ALD is considered as one of the most prevalent causes of liver disease-associated mortality worldwide. Although the pathogenesis of ALD has been intensively investigated, the present understanding of its biomarkers in the context of early clinical diagnosis is not complete, and novel therapeutic targets that can significantly alleviate advanced forms of ALD are limited. While alcohol abstinence remains the primary therapeutic intervention for managing ALD, there are currently no approved medications for treating ALD. Furthermore, given the similarities and the differences between ALD and non-alcoholic fatty liver disease in terms of disease progression and underlying molecular mechanisms, numerous studies have demonstrated that many therapeutic interventions targeting several signaling pathways, including oxidative stress, inflammatory response, hormonal regulation, and hepatocyte death play a significant role in ALD treatment. Therefore, in this review, we summarized several key molecular targets and their modes of action in ALD progression. We also described the updated therapeutic options for ALD management with a particular emphasis on potentially novel signaling pathways. |
| first_indexed | 2024-03-09T20:39:12Z |
| format | Article |
| id | doaj.art-aeca801536e6442fa3890bac1192bc07 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:39:12Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-aeca801536e6442fa3890bac1192bc072023-11-23T23:04:33ZengMDPI AGBiomedicines2227-90592022-10-011010253010.3390/biomedicines10102530Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic PerspectivesYoonji Ha0Inju Jeong1Tae Hyun Kim2College of Pharmacy, Sookmyung Women’s University, Seoul 04310, KoreaCollege of Pharmacy, Sookmyung Women’s University, Seoul 04310, KoreaCollege of Pharmacy, Sookmyung Women’s University, Seoul 04310, KoreaAlcohol-related liver disease (ALD) refers to a spectrum of liver manifestations ranging from fatty liver diseases, steatohepatitis, and fibrosis/cirrhosis with chronic inflammation primarily due to excessive alcohol use. Currently, ALD is considered as one of the most prevalent causes of liver disease-associated mortality worldwide. Although the pathogenesis of ALD has been intensively investigated, the present understanding of its biomarkers in the context of early clinical diagnosis is not complete, and novel therapeutic targets that can significantly alleviate advanced forms of ALD are limited. While alcohol abstinence remains the primary therapeutic intervention for managing ALD, there are currently no approved medications for treating ALD. Furthermore, given the similarities and the differences between ALD and non-alcoholic fatty liver disease in terms of disease progression and underlying molecular mechanisms, numerous studies have demonstrated that many therapeutic interventions targeting several signaling pathways, including oxidative stress, inflammatory response, hormonal regulation, and hepatocyte death play a significant role in ALD treatment. Therefore, in this review, we summarized several key molecular targets and their modes of action in ALD progression. We also described the updated therapeutic options for ALD management with a particular emphasis on potentially novel signaling pathways.https://www.mdpi.com/2227-9059/10/10/2530alcohol-related liver diseasepathophysiologydiagnosisnon-alcoholic fatty liver diseasetherapeutic targetsG protein-coupled receptor |
| spellingShingle | Yoonji Ha Inju Jeong Tae Hyun Kim Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives Biomedicines alcohol-related liver disease pathophysiology diagnosis non-alcoholic fatty liver disease therapeutic targets G protein-coupled receptor |
| title | Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives |
| title_full | Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives |
| title_fullStr | Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives |
| title_full_unstemmed | Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives |
| title_short | Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives |
| title_sort | alcohol related liver disease an overview on pathophysiology diagnosis and therapeutic perspectives |
| topic | alcohol-related liver disease pathophysiology diagnosis non-alcoholic fatty liver disease therapeutic targets G protein-coupled receptor |
| url | https://www.mdpi.com/2227-9059/10/10/2530 |
| work_keys_str_mv | AT yoonjiha alcoholrelatedliverdiseaseanoverviewonpathophysiologydiagnosisandtherapeuticperspectives AT injujeong alcoholrelatedliverdiseaseanoverviewonpathophysiologydiagnosisandtherapeuticperspectives AT taehyunkim alcoholrelatedliverdiseaseanoverviewonpathophysiologydiagnosisandtherapeuticperspectives |